气孔运动受复杂的分子机制调控。研究气孔运动的调控机理，对改善植物抗旱性、培育抗旱新品种有重要理论意义。定位于质膜上的类受体激酶GHR1，属于non-RD类激酶，具有较弱的激酶活性，可以直接磷酸化慢性阴离子通道SALC1，但可以被ABA信号途径中的负调控因子A类PP2C中的ABI2抑制；同时发现，GHR1位于胞外H2O2的下游，而位于钙离子的上游，参与气孔运动的调控。ghr1突变体在暗下气孔开度较野生型的大，说明GHR1也参与了光调控的气孔运动。前期研究发现了三个与GHR1互作的类受体激酶，两个胞质激酶蛋白以及一个H+-APTase和一个CNGC钙离子通道蛋白。初步试验表明，这些蛋白可能和GHR1一起，共同调控气孔运动。对这些蛋白的功能解析、以及它们与GHR1相互关系的分析，会帮助我们进一步明确类受体蛋白激酶GHR1如何传递胞外信号、介导气孔运动的分子机理。

Stomatal movement is regulated by complex molecular mechanisms. Studying the regulation mechanism of stomatal movement will have a significant impact on improving plant drought stress and breeding drought tolerant crops. The plasma membrane localized receptor-like protein kinase GHR1 belongs to the non-RD protein kinase with low activity, which is able to phosphorylate the slow-type anion channel protein SLAC1, but is inhibited by a clade A type PP2C ABI2. GHR1 works downstream of H2O2 and upstream of Ca2+ to modulate stomatal movement. In darkness, ghr1 mutant has bigger stomatal apertures than the wild type, suggesting that GHR1 is also involved in light regulated stomatal movement. Our previous studies identified three receptor-like protein kinases, two cytosolic protein kinases, one H+-ATPase and one CNGC calcium channel protein that interacts with GHR1 in different assays. Our preliminary data indicate that these proteins likely work together with GHR1 to modulate stomatal movement. Further analyzing the biological functions of these proteins and their connections with GHR1 will provide us more information about how GHR1 perceives and transduces the extracellular signals and what molecular mechanisms of GHR1 to regulate stomatal movement.