本项目针对人工关节因摩擦磨损产生的磨屑而引起无菌松动并导致失效的问题，构建一种新型纳米多级结构保护涂层：以生物相容性优良、耐腐蚀和摩擦学性能优异的TaC基纳米复合结构为第一级，纳米复合结构组成具有不同表面拓扑形貌的纳米柱状晶阵列结构涂层为第二级。这种涂层在生物介质中可以充分发挥TaC基纳米复合结构材料的低摩耐磨特性与薄膜表面拓扑形貌的协同作用，达到减磨增强的目的，起到保护人工关节的作用。本研究将倾斜角度沉积技术（GLAD）与传统磁控溅射相结合，实现新型纳米多级结构涂层的一步原位合成；以纳米多级结构涂层的可控生长为基础，探究纳米复合结构形成的热力学机理和纳米柱状晶阵列生长的动力学效应以及二者的交互影响；建立纳米多级结构涂层中微观结构与硬度、韧性及摩擦学性能的关系；揭示涂层的纳米复合结构和表面拓扑形貌的协同作用及在生物介质中流体动力润滑机理；最终为人工关节保护涂层的设计提供科学依据。

The release of very small particles of wear debris from the bearing over a long period of time may cause loosening and eventual failure for the joint replacements. This proposal report is about the investigation on a kind of novel biomedical coating with hierarchy structure: the TaC based nanocomposite structure materials with excellent biocompatible and tribology is the first level structure, the nano-columnar array coating with different surface topography which constituted by nanocomposite structure is the second level. This novel biomedical coating can provide synergistic effects of the tribology of TaC based nanocomposite structure materials and the surface topography to reduce the wear, protect the joint replacements and extend longevity. The biomedical coating with hierarchy structure can be one-step deposited by magnetron sputtering and glancing angle deposition. As a research object, the thermodynamic effect for the formation of nanocomposite structure and the kinetic behavior for the growth of nano-columnar array investigated. The research will reveal the relationship between the microstructure (nanocomposite structure, nano-columnar array) and properties (hardness, toughness and tribology) of hierarchy structure coating. The mechanism of hydrodynamic lubrication in synergistic effect of nanocomposite structure, surface topography and biological media will be explored. The goal of the proposal is to obtain the biomedical coating with hierarchy structure to protect the joint replacements, and to know how to design and apply this kind of coating in the future.