针对中药复方复杂体系药效物质基础研究中存在的问题，围绕"体内有一定暴露水平且具有良好药代属性的活性化合物群是中药复方发挥临床疗效的物质基础"的科学假说，以经典名方血府逐瘀汤为研究对象，整合血清药物化学、微量代谢产物富集制备技术、抗血小板活性高通量评价技术、多成分药代属性评价技术等，从血府逐瘀汤化学成分群、体内化学成分群、具有抗血小板活性的体内成分、具有良好药代属性的体内成分四个层次上，通过整合分析多方面化学与生物效应数据，辨析血府逐瘀汤在大鼠体内的药效物质，从而阐明血府逐瘀汤发挥活血化瘀作用的药效物质基础，为中药药效物质基础研究提供一种新的研究思路，也为血府逐瘀汤现代制剂的二次开发和技术提升提供理论依据和技术支持。

To clarify the effective material basis for Chinese herbal formula, the study will be performed by choosing Xue-Fu-Zhu-Yu decoction as a model on the basis of the scientific hypothesis that the effective material basis of Chinese herbal formula in clinical use consists of the active compounds with the good pharmacokinetic properties and exposure in vivo. By integrating the technology of serum pharmacochemistry, preparation of metabolite, high-throughput screening of the antiplatelet compounds and appraisal of pharmacokinetic of multiple active compounds, the pharmacodynamic basis for activating blood and resolving stasis will be uncovered for Xue-Fu-Zhu-Yu decoction in the study of chemcical basis of Xue-Fu-Zhu-Yu decoction in vitro and in vivo, antiplatelet compounds, and compounds with good pharmacokinetic properties. It will provided a new research perspective for pharmacodynamic studies. It will also offer theoretical basis and technical support for further thorough research and development of modern preparation of Xue-Fu-Zhu-Yu decoction.