全碳季碳手性中心普遍存在于精细化学品、药物中间体以及天然产物结构中；而立体选择性地构建全碳季碳手性中心一直以来是最具挑战性的难题之一；另一方面，有机催化作为目前有机合成中的研究热点之一，由于其具有环境友好、成本低廉、易于操作等诸多优点, 受到了广泛关注。本项目将通过研究有机催化下多组分串联反应，寻求高效率、高立体选择性地构建全碳季碳手性中心的方法;针对不同结构特征的反应底物,广泛地探讨形成全碳季碳手性中心的合成方法,为解决这一难题提供一条有效的途径；通过催化剂的设计、合成以及结构与性能关系的研究,筛选出具有优异催化性能的催化剂体系；此外，针对具有非常重要生物活性的天然产物- Viridin的结构特征,利用所建立的方法学来立体选择性地构建全碳季碳手性中心作为整个合成路线的关键步骤。由此，本项目将为有机催化在天然产物、精细化学品的合成中开辟更为广阔的应用前景。

All-carbon quaternary chiral centers extensively exist in fine chemicals, pharmaceutical intermediates and natural products. However, Enantioselective construction of all-carbon quaternary center has been one of the most challenging research topics in organic synthesis. On the other hand, organocatalysis has attracted so much attention because of its advantages such as environment-friendliness,low cost，and easy operation etc.. In this proposal, the organocatalytic multi-component Domino reaction will be deeply studied to enantioselectively construct the all-carbon quaternary center on various substrates, which could be expected to provide a highly efficient pathway for asymmetric construction of all-carbon quaternary center. The corresponding organocatalysts will be designed, synthesized, and screened to investigate the relationship of structure-activity on the performance of the enantioselective construction of all-carbon quaternary center. Furthermore, this developed methodology will be applied to the first enantioselective synthesis of a natural product-Viridin, a highly biologically active pentacyclofuranosteroid. And this developed methodology will serve as the key step for the whole synthetic sequence. The studies in this proposal would significantly facilitate the application of organocatalysis in the synthesis of natural products and fine chemicals.