可见光氧化还原催化具有条件温和、自由基产生效率高的优点，但反应区域可控性较差；有机催化在多种化学转化中具有底物活化多样性和区域特异性的优势，但反应活性较低导致反应时间长。基于此，本项目利用可见光催化和有机催化各自特有的底物活化特性和反应活性差异，设计合成系列以手性氨基酸为母体结构的新型光-有机催化剂，首次系统研究光-有机双催化体系的匹配性，并通过基底材料辅助增强两种催化体系的协同催化效果；分别以“独立活化”及“协同活化”模式，通过有机催化形成烯胺对光催化下生成的自由基中间体实施反应区域精准定位，利用多位点反应底物实现协同催化多步串联环化反应，以多元的环化模式构建结构复杂的2-4元碳环及杂环体系；开发基于光-有机协同催化的流体连续反应绿色化工过程。项目的完成将丰富高效双催化体系的设计策略和协同催化的理论体系，为复杂精细化学品的合成提供新的解决方案和途径，拓展可见光催化在精细化工领域中的应用。

Visible-light photoredox catalysis features mildness in reaction conditions and high efficiency in generating radicals, but difficulty in controlling the reaction sites. Organocatalysis is demonstrating wild scope of activating substrates and high regioselectivity as well as relatively lower activity causing long reaction time. Therefore, based on their characteristic activation mode and reactivity difference between visible-light photocatalysis and organocatalysis, a series of novel photo-organocatalysts derived from chiral amino acids are designed and to be prepared in this project. The systematic studies on the mergence of these two catalytic systems will be conducted for the first time, which will be strengthened by virtue of specific base materials. Two activation modes - “individual activation” and “synergistic activation” are employed to precisely position the reaction sites of the radical intermediates through the formation of enamine by organocatalysis. And domino cyclization process via synergistic catalysis will be realized by using the substrates with multiple reaction sites. As a result, complex multicyclic ring systems can be constructed through various cyclization pathways. The synergistic catalysis-based flow reaction will be investigated to facilitate the green chemical process. The completion of this proposal will provide design strategy for efficient binary catalysis, enrich the fundamental theories for synergistic catalysis, and afford innovative pathways for the complex fine chemicals, which will find broad application in fine chemical engineering.