基于三嗪基共价有机骨架核壳型液相色谱固定相的制备及色谱性能

本课题拟以三聚氰氯和多种多胺结构的刚性小分子为有机砌块，通过连续亲核取代反应在硅胶表面原位生长三嗪基共价有机骨架包覆层，制备一系列兼具球形柱效和多孔有机骨架分离性能的高效液相色谱固定相填料。以多种化合物为溶质探针，在正相、反相、亲水、离子交换等多种分离模式下考察固定相的色谱性能，比较不同结构固定相在色谱选择性的异同点和变化规律；深入探讨新型固定相的色谱分离动力学和热力学过程及固定相的分离机理；开发基于三嗪基共价有机骨架液相色谱固定相的复杂体系分离分析新方法。本项目的实施，不仅可为复杂体系的分离分析提供新的分离介质，同时扩展了共价有机骨架材料的应用范围，具有重要的学术意义和实际应用价值

In this project, by using cyanuric chloride and multi amino compounds as organic blocks through continuous nucleophilic substitution reaction, covalent triazine-based frameworks coating will be grown in situ on the surface of silica to prepare a series of core-shell stationary phases for HPLC. The new materials share the advantages of the good column packing properties of the uniform monodisperse silica microspheres and unique molecular recognition performance of covalent triazine-based frameworks. The chromatographic performance of the stationary phases will be investigated by using a variety of solutes as probe in a variety of separation modes such as normal, reverse, hydrophilic, ion exchange and so on. The selectivity comparison between different stationary phases will also be investigated. The chromatographic kinetics, thermodynamics and separation mechanism of the new stationary phases will be discussed in depth. A series of new separation and analysis methods for complex matrix based on the new stationary phases will be developed. The implementation of this project can not only provide a new separation medium for the separation and analysis of complex samples, but also extends the application range of the covalent organic framework material, which has important academic significance and practical application value.