老龄化与老年病逐年剧增，而神经退行性疾病是主要表征之一。阿尔兹海默（AD）发生与诊疗研究仍是长久性的世界难题。海马神经干细胞增殖与脑源性神经营养因子BDNF表达能够改善AD鼠认知功能。项目组前期发现，天然产物紫檀芪及其结构衍生物酰胺化苯乙烯QLX-N能促进内源性神经干细胞生长、提高脑源性神经营养因子BDNF海马组织表达水平、缓减AD鼠的学习记忆损伤，但其作用方式与机制仍不清晰。基此，本课题拟采用QLX-N荧光示踪技术，追踪QLX-N与海马神经营养因子分泌的组构配比，解析QLX-N促进神经干细胞增殖、分化、迁移，缓减AD发生的功能作用和机制。为基于内源性干细胞新分子路径的AD神经营养改善策略提供科学与实践支持，为靶向神经干细胞的AD天然药物研发提供新思路。

Aging and geriatric diseases have increased year by year, and neurodegenerative diseases are one of the most important types associated with aging. The onset and treatment of AD still remain a long-standing world problem. Hippocampal neural stem cell proliferation and brain-derived neurotrophic factor BDNF expression can improve cognitive function in AD rats model. In the early stage of the project,, it was found that the natural product pterostilbene and its structural derivative, amidated styrene QLX-N, could promote the growth of endogenous neural stem cells, increase the expression level of brain-derived neurotrophic factor BDNF in hippocampus tissue, and alleviate learning and memory impairment in AD rats. But the underlying mechanism of how this compound works in the brain remains unclear. Based on these facts, QLX-N fluorescence tracer technology is used to track the composition of QLX-N and hippocampal neurotrophic factor secretion, analyze the functional role and mechanism of QLX-N in promoting proliferation, differentiation and migration of neural stem cells and alleviating AD. We aim to provide scientific and practical support for neurotrophic improvement strategies for AD patients based on new molecular pathways of endogenous stem cells, and to provide new insights for the development of natural drugs for the treatment of AD targeting neural stem cells.