肺癌居恶性肿瘤死亡率之首，易复发转移是导致其预后不良的重要原因之一。金复康口服液是全国著名肺癌专家刘嘉湘教授研发的治疗肺癌的中成药。前期研究表明，"金复康"不仅能延长晚期肺癌患者的生存期，还能有效抑制III期肺癌患者的远处转移。肿瘤血管生成是肿瘤转移的重要机制之一，"金复康"由12味药组成，其中哪些药物或者哪些药物组合是通过影响肿瘤血管新生而发挥抑制转移作用的，目前尚不清楚，如果能从明确的作用机制发现有效的药物组合，将对形成抗肺癌转移新药有重要意义。因此本课题以肿瘤新生血管生成这一关键肿瘤转移机制为研究切入点，利用方便观察新生血管生成的斑马鱼模型开展研究，引入工程控制算法筛选"金复康"中抗肿瘤血管新生的中药或药物组合形成优化处方，同时运用肺癌转移动物模型，验证并预期优化后的复方比原方"金复康"具有更好的肿瘤转移抑制作用，其影响肿瘤血管新生的机制明确，为今后开发抗肺癌转移新药奠定研究基础。

Lung cancer ranks firstly in cancer mortality,the easy recurrence and metastasis are one of the important reasons for its poor prognosis. Jin Fu Kang Oral Liquid is a proprietary Chinese medicines that was researched and developed by Professor Liu Jiaxiang who is the expert of nationally renowned lung cancer treatment. Previous studies showed that "Jin Fu Kang"not only can prolong survival time of patients with advanced lung cancer but also can effectively inhibit distant metastasis of Phase III lung cancer patients. Tumor angiogenesis is one of the important mechanisms of tumor metastasis. "Jin Fu Kang" be composed of 12 herbs, it is not clear that Which drugs or which drug combinations play inhibiting metastasis role by affecting tumor angiogenes. If effective drug combinations can be found through a clear mechanism，it is very important will be the formation of anti-lung metastasis of new drugs.Therefore, the entry point of the program is tumor angiogenesis which is the key mechanism of tumor metastasis，using Zebrafish model because it is easy to observe for researching on tumor angiogenesis, introducing engineering control algorithm filter herbs and herbal combination of "Jin Fu Kang", which can anti-angiogenesis of tumor and form the optimizing prescription,at the same time using the animal model of lung cancer metastasis, proving validation optimizing compound has better inhibition tumor metastasis than the original "Jin Fu Kang" and has explict mechanism of anti-angiogenesis of tumor ,laying the research foundation for the future development of new drugs of anti-lung cancer metastasis.