本项目拟研究手性胍催化的高效、高对映选择性的不对称Brook反应，发展新型高效的不对称有机合成方法；探索手性胍自身结构的特异性和有机硅化合物结构改变对Brook反应的影响，导向性地构筑手性季碳化合物、联烯化合物、烯丙基化合物、环状化合物以及含杂原子的化合物；通过控制实验和理论计算，合理解释Brook反应机理和高对映选择性的原因，总结反应规律；进一步扩展其它反应类型的Brook反应，并实现其在天然产物和药物分子合成中的应用。

This proposal relates to the chiral guanidine-catalyzed Brook rearrangement with excellent enantioselectivity, and a new high efficient and asymmetric methodology will be developed. For the synthesis of chiral quaternary carbon compounds, allenic compounds, allyl compounds, cyclic and heteroatom compounds, the impact of structural changes of chiral guanidine and organosilicon compounds will be explored. To further explain the reaction mechanism and enantioselectivity, experimental controlling and theoretical calculation will be the powerful tools in this reaction. Finally, the new types of Brook reaction will be developed and its application will be realized in the synthesis of natural products and drug molecules.