我国混合人群转录组调控网络研究方法的建立

基因的表达变化是物种进化的重要体现，如何揭示人群DNA水平上的遗传变异对基因表达水平以及最终表型的调控模式，一直都是遗传学上的研究热点。同时，生物体的大部分功能都是受多个基因的影响和调控，因此只有通过研究转录组的遗传调控网络，才能最终阐明复杂性状（如疾病）发生和发展的机制。普通人群的表型变异常常会受到系统的非遗传因素（如环境）的影响，由人群融合产生的混合人群不但性状变异和基因变异都显著高于普通人群，而且所处的环境是相对一致的，从而可以在很大程度上消除环境因素造成的系统干扰，因此混和人群成为研究转录组调控网络的一个理想模型。目前，还没有针对混和人群转录组调控网络的研究方法，因此本项目拟采用中国混合人群为研究模型，结合混合人群在遗传特征方面的优势，发展计算方法，构建中国混和人群转录组的调控网络，为今后同类研究提供方法基础。

Gene expression change is an important manifestation of the evolution of species. How to reveal the human regulatory pattern of genetic variation on the DNA level on the gene expression changes and ultimate phenotype has always been a hot topic in genetics. Meanwhile, as the functions of most organisms are regulated by mutiple genes, we are able to clarify the mechanism of the occurrence and development of complex diseases，by identifying transcriptome regulatory network. The phenotypic variation carried by general populations may be caused by non-genetic factors such as the environment, while the admixed populations that are generated by populations admixing have higher trait and genetic variation than the general populations, also the environmental impact is consistently affecting the individuals in admixed populations, which can eliminate system inference caused by environmental factors largely. These advantages make them the best model to study transcriptome regulatory network. Currently, there is no methodology to study the transcriptome regulatory network of admixed populations, therefore, combining the unique genetic structures of admixed populationse, we intend to take chinese admixed population as a research model to develop research methodology and build transcriptome regulatory network of chinese admixed populations, which will help to provide a methodological basis for future similar studies.