光污染日益成为较为严重的公共卫生问题，探讨视网膜光化学损伤（RPD）的预防措施尤为重要。前期研究证实，黑米皮花青素提取物（BRACs）对RPD能产生一定的防护效应。预实验发现，花青素的主要活性成分Delphinidin能维持RPD视网膜组织结构完整性，降低焦亡标志物Caspase-1表达。因而推测，Delphinidin能通过调节氧化-抗氧化系统、抗凋亡、抗焦亡途径对RPD产生防护效应。本项目利用体内体外RPD模型，首先证实Delphinidin对RPD的防护效应，然后探讨Delphinidin通过调节氧化-抗氧化系统、抗AP-1/NF-κB/Caspase-3凋亡通路、抗NLRP3/Caspase-1/IL-1β/IL-18焦亡通路防护RPD的分子机制。研究结果不但丰富从凋亡到焦亡的RPD病理机制，而且证实Delphinidin具有抗焦亡作用新的生物学功能，为光污染提供有效预防措施。

It has been considered increasingly that light pollution is a severe public health problem. Herein, it is very important to explore the preventive measure of retina photochemical damage (RPD). Our previous experiment has been demonstrated that black rice anthocyanidins (BRACs) has the protective effects on RPD. Furthmore, the preliminary experiment has discovered that, delphinidin, as a major functional active component, might maintain the tissue structural integrity of retina, down-regulates the mRNA and protein expression of Caspase-1 in RPD. Therefore, we furtherly suppose that delphinidin also has the protective effects on RPD via regulating the oxidative and anti-oxidative system, anti-apoptosis and anti-pyroptosis. Based on RPD model in vivo and in vitro, the present exprement firstly demonstrate the protective effects of delphinisin on RPD, and then investigate the underlying molecular mechanism via anti-oxidative, anti-AP-1/NF-κB/Caspase-3 apoptosis signal pathway and anti-NLRP3/Caspase-1/IL-1β/IL-18 pyroptosis signal pathway. The results not only will abundant the pathomechanism of RPD from aopotosis to pyroptosis, but also will confirm the anti-pyroptosis new biological function of delphinidin, thus provide available preventive measure of light pollution.