黄单胞杆菌型细菌病害危害着全球400余种植物，造成了农作物的大幅减产或绝收。多数黄单胞杆菌利用转录激活型效应因子（TALEs）调控了植物的畸形发育，加速了病菌的侵染。申请者前期研究发现，bHLH转录因子家族基因SlUPA-like是黄单胞杆菌TALEs型效应因子AvrBs3的靶基因，过量表达番茄SlUPA-like基因能导致番茄畸形发育和提高番茄对黄单胞杆菌的易感性，但其作用机理尚不清楚。本研究以黄单胞杆菌易感植物番茄为试验材料，运用现代分子生物学手段，分析AvrBs3作用于SlUPA-like基因启动子的靶位点，并挖掘SlUPA-like的生物学功能，鉴定它的靶基因与互作蛋白，构建SlUPA-like调控番茄畸形生长发育的代谢网络，为阐明番茄感病的分子机理和提高番茄的抗病性奠定基础。

Xanthomonas，as a pathogenic bacteria, can infect more than 400 species of plants and substantially causes crop failure or even no harvests. The phenotype of plant developmental malformation were regulated by most Xanthomonas through the Transcription Activator-like Effectors (TALEs), which also together with rapid proliferation of pathogenic bacterial. In previous study, we found a gene named SlUPA-like , which is the target of AvrBs3 ( One member of TALEs). Over-expressed SlUPA-like gene in tomato plants led to developmental malformation and susceptibility of plants to Xanthomonas. But the Molecular Mechanisms is not clearly. In this study, the regulation mechanism of AvrBS3 and SlUPA-like will be analyzed. The regulatory network of SlUPA-like will be constructed through identifying its target genes and interacted proteins by modern biotechnology. Further biological function of SlUPA-like will be identified in this study. .The results of this research will not only enrich the molecular mechanism of plant malformation induced by SlUPA-like, but also be benefit to selection of disease-resistant plants to Xanthomonas.