尖锐湿疣是我国最常见的性传播疾病之一。近年来全国各地外出务工人员和留守配偶已成为不容忽视的性传播疾病高危群体，尖锐湿疣在外出务工人员及其配偶中尤为高发，但相关的研究极少且多基于性病皮肤病就医人群，罕有基于自然人群的流行病学研究资料。超过90%的尖锐湿疣由人乳头瘤病毒6型和/或11型（HPV6/11）感染引起，高危性行为是HPV6/11传播的主要危险因素。阐明自然人群的HPV6/11感染状况及配偶间经性传播动力学对于尖锐湿疣的预防控制具有重要意义。此前申请人依托单位已在广西柳州市城乡自然人群中开展HPV6/11及尖锐湿疣流行情况调查，本项目拟在此调查基础上，建立HPV6/11感染者及其固定性伴的前瞻性研究队列，以阐明HPV6/11感染者及其固定性伴之间的感染经性传播动力学，包括固定性伴间HPV6/11感染一致性、感染持续时间、男传女及女传男的概率等科学问题，为尖锐湿疣的防控策略制定提供依据。

Genital warts (GW) are the most common sexually transmitted infections with a substantial burden of disease in China. In recent years, migrant workers and their spouses had been recognized as a major contributor to sexual transmitted disease in China. The prevalence of GW was especially high in migrant workers and their spouses, however, the GW epidemiology research are scare in this group population and often hospital based studies. To date, few studies had been carried out to assess the epidemiology of GW in general population in China. HPV 6 and 11 accounted for over 90% of GW cases, and high risk sexual behavior are the primary route of HPV6/11 infection. It is important to understand the prevalence, incidence and natural history of HPV6/11 infection to assess the burden of GW. Knowledge about HPV6/11 transmission dynamics in heterosexual couples is important for GW prevention and control strategy. Our team had carried out a prospective study to assess the prevalence and incidence of GW and HPV prevalence in general population in Guangxi. This study plans to recruit HPV6/11 DNA positive individuals (index partners) in pervious study and their sexual partners. By following them for two year, to examine the concordance of HPV6/11 infection, the persistence infection rate and HPV6/11 transmission rates in couples, including female-to-male transmission and male-to-female transmission rate. These data from this study can elucidate sexual transmission dynamics of HPV6/11 in general population systematically and provide clues for GW prevention and control strategy.