Incidence of anogenital warts in Liuzhou, south China: a comparison of data from a prospective study and from the national surveillance system.
Incidence of anogenital warts in Liuzhou, south China: a comparison of data from a prospective study and from the national surveillance system.
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中国南方柳州肛门生殖器疣的发病率：前瞻性研究数据与国家监测系统数据的比较
DOI：
10.1038/emi.2017.100
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发表时间：
2017-12-20
影响因子：
13.2
通讯作者：
Xia N
中科院分区：
文献类型：
--
作者：
Wei F;Sheng W;Wu X;Yin K;Lan J;Huang Y;Ma X;Zheng Y;Zhuang S;Huang S;Su Y;Li M;Wu T;Zhang J;Xia N
为了确定中国普通人群中肛门生殖器疣 (AGW) 的发病率，我们比较了一项前瞻性研究和国家法定疾病报告系统 (NNDRS) 的数据。 2014年5月至2016年3月，对来自中国柳州的2378名18-55岁女性和2309名男性进行了队列研究，每隔6个月进行3次定期访视。并进行问卷调查，收集入组访视时的AGWs诊断史。并对柳州市2006年至2015年报告的AGW病例数据进行了分析。总体而言，前瞻性研究、过去 12 个月自我报告诊断和 NNDRS 中 AGW 的发生率分别为每 1000 人年 1.26 例（95% 置信区间 (CI)：0.16–2.37）、2.35（95% CI：1.17–4.20）和 0.183（95% CI： 0.178–0.187），分别。在所有 AGW 活检样本中均发现人乳头瘤病毒 6 型或 11 型 (10/10)。女性AGW的发病时间较早，且累积风险在年轻时随随后的每个较年轻出生队列增加更快（P<0.0001），而不同男性出生队列中观察到轻微差异（P=0.0785）。个人及其性伴侣的性行为与自我报告的 AGW 密切相关。我们的研究表明，中国AGWs的发病率与发达国家一样高，而基于国家监测系统的数据严重低估了AGWs的真实疾病负担。
To determine the incidence of anogenital warts (AGWs) in the Chinese general population, we compared the data from a prospective study and from the National Notifiable Disease Report System (NNDRS). A cohort study including 2378 women and 2309 men aged 18–55 years old enrolled from Liuzhou, China, was conducted with three scheduled visits at 6-month intervals from May 2014 to March 2016. And, a questionnaire survey was performed to collect the diagnosis history of AGWs at the enrollment visit. The data on reported AGW cases of Liuzhou in the NNDRS from 2006 to 2015 were also analyzed. Overall, the incidence rates of AGWs in the prospective study, in the self-reported diagnosis during past 12 months and in the NNDRS were 1.26 per 1000 person-years (95% confidence interval (CI): 0.16–2.37), 2.35 (95% CI: 1.17–4.20) and 0.183 (95% CI: 0.178–0.187), respectively. Human papillomavirus 6 or 11 were found in all the AGW biopsy samples (10/10). The onset time of AGWs in women was earlier, and the cumulative risk increased more quickly at a young age along with each subsequent younger birth cohort (P<0.0001), whereas slight differences were observed in the different male birth cohorts (P=0.0785). The sexual behavior of individuals and their sexual partners had a strong relationship with self-reported AGWs. Our study indicates that the incidence of AGWs in China is as high as that in developed countries, and the data based on the national surveillance system seriously underestimate the real disease burden of AGWs.
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DOI：
10.1056/nejmoa0909537
发表时间：
2011-02-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giuliano AR;Palefsky JM;Goldstone S;Moreira ED Jr;Penny ME;Aranda C;Vardas E;Moi H;Jessen H;Hillman R;Chang YH;Ferris D;Rouleau D;Bryan J;Marshall JB;Vuocolo S;Barr E;Radley D;Haupt RM;Guris D
通讯作者：
Guris D
影响因子：
3.6
作者：
Canvin, M.;Sinka, K.;Mesher, D.
通讯作者：
Mesher, D.
影响因子：
3.1
作者：
Baandrup, Louise;Blomberg, Maria;Kjaer, Susanne K.
通讯作者：
Kjaer, Susanne K.
影响因子：
56.3
作者：
Donovan, Basil;Franklin, Neil;Fairley, Christopher K.
通讯作者：
Fairley, Christopher K.
影响因子：
3.6
作者：
Pirotta, M.;Ung, L.;Garland, S.
通讯作者：
Garland, S.