强迫症是一种严重的精神疾病，已被多项研究证实存在显著的决策功能异常；认知行为治疗（CBT）可以改变个体的决策功能，是强迫症的有效治疗技术，然而临床实践中仍有一些患者疗效不佳，这些患者可能存在决策功能异常行为模式及具有不同于治疗反应良好患者的神经生物学特征。本项目将对首诊强迫症患者进行CBT治疗12周，采用纵向追踪采集患者在治疗前后决策功能、症状变化，以及事件相关电位、结构、功能磁共振等多模态脑影像数据。对多模态数据进行整合分析，确定对疗效预测具有鉴别价值的神经生物学标志，建立强迫症CBT疗效的预测模型。本研究的顺利实施将具有重要的理论和实践价值。首先，可以丰富已有强迫症病理生理学的理论模型，阐清强迫症的临床症状与决策功能之间的关系；其次，有助于揭示影响强迫症疗效的病理机制，获得对疗效具有准确预测作用的神经生物学标记，为有效、精确治疗强迫症提供实验依据，减少无效治疗所导致的经济与时间损失。

Obsessive Compulsive Disorder(OCD) is a serious mental illness, which has been confirmed having significant decision-making dysfunction. Cognitive behavior therapy (CBT) has been shown to be able to alter individual decision-making functions and is an effective treatment for OCD. However, the curative effect of CBT is still poor for some patients with OCD, who may be different from those patients responding well to CBT treatment in decision-making function and neural biological characteristics. Follow-up method is adopted in this project, OCD patients will be treated with CBT for 12 weeks, finish decision making test, and be collected multimodal brain images such as event related potentials, structure and functional magnetic resonance imaging before and after CBT therapy. After consolidation analysis of multimodal data, we can determine the effects of prediction with valuable neurobiological marker and establish the forecast model of CBT curative effect. This project will enrich the existing pathophysiology theory model of OCD, and help to clarify the relationship between clinical symptoms of OCD and decision-making disability. Also, the neurobiological mechanisms influencing OCD curative effect will be explored, and biological markers for predict CBT curative effect accurately will be found. Therefore, this project provide the choice basis for OCD and reduce ineffective treatment with loss of economic and time.