强迫性人格障碍影响强迫症的临床症状和治疗效果，但其中的神经机制尚不明确。本项目采用自评与临床晤谈相结合的方式筛选出强迫症伴强迫性人格障碍、强迫症不伴强迫性人格障碍、强迫性人格障碍和普通个体共四组作为研究对象，实施反映执行功能子成分的多个任务（包括反映行为抑制功能的停止信号任务，反映认知抑制功能的Stroop任务，反映刷新功能的n-back任务以及反映转换功能的线索任务转换范式），对受试完成任务时的行为学数据、事件相关电位(ERPs)与功能磁共振(fMRI)进行采集。并追踪测查所有强迫症在10周的SSRI类药物治疗后心理测验、执行功能任务行为学、ERPs及fMRI的变化。对所收集数据运用动态因果模型和独立成分分析等方法进行分析处理，整合构建出强迫症、强迫性人格障碍执行功能受损的脑神经网络模型，全面揭示强迫性人格障碍影响强迫症发生、发展、预后的神经机制。

The Obsessive-Compulsive Personality Disorder (OCPD) affected the effect of the clinical symptoms and treatment of Obsessive-Compulsive Disorder (OCD),while the neural mechanisms are still unclear. By combining self-report assessments and clinical screening interviews, we will recruit patients with OCD or with OCPD or with both diseases, and healthy subjects. Then several executive function tasks, including the stop signal task reflecting behavior inhibition, the Stroop task reflecting the cognitive inhibitory, the n-back task reflecting the updating and cued task-switching paradigm reflecting the shifting, will be finished by subjects.Event Related Potentials (ERPs) and functional magnetic resonance (fMRI) data will be collected when subjects are performing the tasks.Selective Serotonin Reuptake Inhibitors(SSRI) medications will be used in all patients with OCD, then, 10 weeks later, the psychological assessment, executive function tasks and records of ERPs and fMRI will be arranged again. Finally, the dynamic causal model and independent component analysis will be used to analyze the collected data and created the damaged brain network model of OCD and OCPD on execution functions, which will help fully disclose the neural mechanism of OCPD affecting the occurrence, development and prognosis of OCD.