随着合成化学与纳米医学的飞速发展，高分子基纳米载体在生物医学成像、诊断、以及药物输送等领域中的应用研究受到越来越多的关注。本项目中，拟制备多种结构稳定含亲水性螺旋聚异腈的二嵌段共聚物，借助共胶束化与自组装手段，获得一系列结构明确、同时含有两种染料分子与药物分子、以及兼具高效跨膜性和靶向性的功能型纳米复合胶束，使得该胶束同时具有对肿瘤部位的荧光、近红外、光声多模式成像与光热治疗、化学治疗协同的“诊疗一体化”功能。将详细研究新型嵌段共聚物合成的可控性，优化组装条件及参数以期获得载药率高、成像灵敏度及分辨率高、光热转换效果好、光热与化学治疗协同的“诊疗一体化”纳米试剂；此外，还将详细探讨亲水性螺旋聚异腈链与胍基、叶酸分子的协同作用，建立三者之间的联系，获得基础数据；该系列研究成果将为癌症的早期诊断与干预治疗提供一种基于螺旋聚异腈的新型纳米试剂。

With the rapid development of synthetic chemistry and nanomedicine, polymer based nanocarriers have attracted increasing attention in the fields of biomedical imaging, diagnosis, and drug delivery. Herein, several kinds of diblock copolymers containing stable hydrophilic helical poly(isocyanide) chains will be prepared. By means of co-micellization and self-assembly approaches, well-defined spherical complex micelles with high efficient cell-penetrating and targeted performance, as well as individual dyes and anti-cancer drugs encapsulated can be achieved, which endow them fluorescent, near-infrared, and photoacoustic multi-mode imaging ability, and synergistic photothermal- and chemo-therapy functionalities. We will investigate the controlled chain growth manner of diblock copolymers in detail and optimize the assembly conditions and parameters to achieve multifunctional theranostic nano reagent. Moreover, the relationship of helical chain, guanidine group, and folic acid will be established. We speculate that the developed platform with combined advantages including promoted membrane permeation, targeted performance, fluorescent and photoacoustic imaging, drug delivery, photothermal therapy, as well as chemotherapy may indeed be a new encouraging alternative to ablation of tumor tissue.