Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications
Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications
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功能导向的肿瘤微环境响应性聚合物纳米组装：工程与应用
DOI：
10.1007/s10118-018-2035-9
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发表时间：
2018-03
影响因子：
4.3
通讯作者：
Yin Jun
中科院分区：
文献类型：
--
作者：
Zhang Wen Ming;Zhang Jian;Qiao Zhu;Yin Jun
The excellent drug encapsulation, prolongedin vivocirculation time, enhanced pharmacokinetics, and reduced adverse effects make the polymeric assemblies ideal carriers in nanomedicine, and become an emerging research field with rapid development.In vivo, the polymer nanoassemblies will experience five steps, including circulation in the blood, accumulation in the tumoral site, penetration into the deep tumor tissue to reach cancer cells, internalization into cancer cells, and intracellular drug release. However, although tremendous efforts have been made to the material design, currently available carriers still have difficulties in fulfilling all of the requirements. Moreover, the long-standing dilemma of the synchronized stability and permeability of vesicles is still a big challenge, which confused researchers for a long time. This feature article focuses on the recent progress of single- or multi-stimuli triggered theranostic platforms, and the extracellularly reengineered shell-sheddable polymeric nanocarriers are systematically discussed. The perspectives for future developments in the nanocarriers functioned with artificial helical polymers (the potential cell-penetrating peptides mimics) are also proposed. We speculate that this feature article can fit the interesting of diverse readers and a guideline for the design of next generation of drug nanocarriers.
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