基本情绪和视觉基本单元的相互作用及“大范围首先”的皮层下通路神经表达

本项目将集中研究基本情绪和视觉认知基本单元的相互作用，特别是恐惧情绪和拓扑性质知觉的相互作用。根据“大范围首先”的视觉认知拓扑结构和功能层次理论，我们将以拓扑不变性质为基础的各级几何不变性质（按由大范围到局部的结构稳定性秩序，包括拓扑、射影、仿射、欧氏不变性质）为视觉基本变量，以发现“大范围首先”的图形结构优势效应为主要实验范式，揭示基本情绪（恐惧、愤怒、厌恶、高兴等）和视觉认知的相互作用，特别是恐惧情绪和拓扑性质知觉的相互作用。本项目将超越经典视皮层通路模型，在恐惧情绪和拓扑性质知觉相互作用的行为实验基础上，集中揭示“大范围首先”的皮层下通路的神经表达。本项目强调结合多种进化水平的模式生物（斑马鱼，ipRGC-only小鼠，猴）和多种脑成像方法（7T磁共振，清醒猴功能磁共振，斑马鱼钙离子光成像，从细胞分子遗传水平的全脑神经表达成像），揭示皮层下通路“大范围首先”功能的系统、决定性的证据。

To address the general and basic question of “how emotion and cognition interact and are integrated in the brain”, this proposal proposes to focus our study on the interaction between primitives of visual cognition and primary emotions, particularly the interaction between the fear emotion and the topological perception. We will apply, following the global-first topological approach, the invariants at different geometrical levels (include, from global to local, topological, projective, affine, and Euclidean invariants) as primitives of vision, and adopt the configural superiority effects as a main paradigm, to measure their interactions with different emotions (fear, angry, disgust, and happy), highlighting the interaction between the fear emotion and the topological perception. Further more, based on the behavioral finding about the interaction between the fear emotion and the topological perception, the project will reveal, beyond classical cortical visual pathways, the subcortical pathway, as global-first neural correlation of fear emotion and topological perception. Various animal models (zebrafish, mouse, and non-human primate) and integrating multi-modalities of neuro-imaging (7T fMRI, fMRI with waking-monkey, optical imaging, and ipRGCs genetical manipulation) will be used to collect systematical and decisive evidence for the subcortical pathway as the global-first neural representation.