Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas.
Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas.
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穹窿的改变会导致金刚质颅咽管瘤患者默认模式网络的破坏。
DOI：
10.1016/j.nicl.2022.103215
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发表时间：
2022
影响因子：
4.2
通讯作者：
Gui, Songbai
中科院分区：
文献类型：
--
作者：
Kang, Jie;Cao, Lei;Yuan, Taoyang;Jin, Lu;He, Yanjiao;Liu, Xing;Zhang, Cuiping;Chen, Nan;Ma, Guofo;Qiao, Ning;Zhang, Bochao;Wu, Wentao;Shi, Yuanyu;Gao, Hua;Li, Chuzhong;Zhang, Yazhuo;Zuo, Zhentao;Gui, Songbai
侵袭性ACP患者的认知能力明显降低。DMN的破坏与ACP患者的认知功能下降相关。穹窿的改变导致ACP患者DMN的破坏。摘要颅咽管瘤是一种罕见的胚胎性肿瘤，常发生于下视丘。ACP患者下丘脑受累（HI）相关认知功能下降的潜在神经基础尚不清楚。我们的目的是联合收割机的多模态神经影像学和ACP的组织学特征，探讨HI相关的认知功能下降的潜在神经基础。45例原发性ACP患者（侵入性，23例;非侵入性，22例）和52例健康对照受试者（HC）被纳入横断面研究。HC和非侵入性ACP（NACP）患者的认知领域无显著差异。侵袭性ACP（IACP）患者的工作记忆表现（WM，p = 0.002）显著低于NACP患者。WM下降与默认模式网络（DMN）中内侧颞叶（MTL）子系统的破坏相关（r = 0.45，p = 0.004）。穹窿的径向扩散率增加，表明脱髓鞘过程，与MTL子系统的破坏相关（r =-0.48，p = 0.002）。我们的研究表明，穹窿改变与ACP患者的DMN破坏和HI相关的认知下降有关。侵入下丘脑的ACP可以提供一种自然的疾病模型，以研究HI相关的认知下降的潜在神经基质。
The patients with invasive ACP showed significantly lower cognitive performance. The disruption of DMN was correlated with the cognitive decline in patients with ACP. The fornix alterations induce the disruption of DMN in patients with ACP. Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of the hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine the multi-modal neuroimaging and histological characteristics of the ACP to explore the potential neural substrate of the HI-related cognitive decline. 45 patients with primary ACPs (invasive, 23; noninvasive, 22) and 52 healthy control subjects (HCs) were admitted to the cross-sectional study. No significant difference in cognitive domains was observed between HCs and patients with noninvasive ACPs (NACP). Patients with invasive ACPs (IACP) showed significantly lower working memory performance (WM, p = 0.002) than patients with NACP. The WM decline was correlated with the disruption of the medial temporal lobe (MTL) subsystem in the default mode network (DMN) (r = 0.45, p = 0.004). The increased radial diffusivity of the fornix, indicating demyelinating process, was correlated with the disruption of the MTL subsystem (r = -0.48, p = 0.002). Our study demonstrated that the fornix alterations link DMN disruption to HI-related cognitive decline in patients with ACPs. ACPs that invade the hypothalamus can provide a natural disease model to investigate the potential neural substrate of HI-related cognitive decline.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
DOI：
10.1016/j.jalz.2011.05.2416
发表时间：
2012
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Mielke MM;Okonkwo OC;Oishi K;Mori S;Tighe S;Miller MI;Ceritoglu C;Brown T;Albert M;Lyketsos CG
通讯作者：
Lyketsos CG
影响因子：
4.8
作者：
Qi H;Liu H;Hu H;He H;Zhao X
通讯作者：
Zhao X
影响因子：
14
作者：
Chiesa, Patrizia A.;Cavedo, Enrica;Younesi, Erfan
通讯作者：
Younesi, Erfan
影响因子：
4.1
作者：
Giese, Henrik;Haenig, Benjamin;Zweckberger, Klaus
通讯作者：
Zweckberger, Klaus