急性主动脉夹层血清miRNA表达谱和功能研究及其临床转化研究

主动脉夹层是一种少见但病情凶险的疾病，一旦发病总体死亡率和手术相关死亡率都非常高。在我国，主动脉夹层好发于高血压人群，并且随着高血压人群的扩大，主动脉夹层的发生率也逐年升高。正确认识主动脉夹层，首先需要明确其病理生理特点，围绕此方面的机制研究从不同角度阐释了主动脉夹层的分子机制。miRNAs是一类长度为18-25个核苷酸的非编码小RNA的总称，目前研究显示miRNAs广泛存在与机体各组织器官中，参与细胞增殖、分化、凋亡和相关生物学功能的调控。血清miRNA作为miRNA的一种存在形式，被作为血清标志物广泛用于临床及基础研究。我们的前期研究发现了血清miRNA和急性主动脉夹层之间可能存在的联系，但需要更进一步的研究来揭示急性主动脉夹层患者血清miRNA表达谱及有变化意义的miRNA的生物学功能，以及转化为临床应用所需。

Aortic dissection is a rare but dangerous disease, the overall mortality and surgery-related mortality are very high. In China, aortic dissection occurs mostly in hypertension population, and with the expansion of the hypertension population, the incidence of aortic dissection has increased year by year. Correct understanding of aortic dissection, you first need to clarify its pathophysiological characteristics, different researches explain the molecular mechanisms of aortic dissection. miRNAs are a class of small non-coding RNA containing 18-25 nucleotides, the current study shows that miRNAs exist widespread in body tissues and organs and participate the regulation of cell proliferation, differentiation, apoptosis. Serum miRNAs is a form of miRNA, which is widely used in clinical and basic research as serum marker. Our previous studies have found a possible link between serum miRNA and acute aortic dissectio, but further research is needed to reveal the serum miRNA profiling and biological function in patients with acute aortic dissection for translating to clinical application.