前期研究发现具有丰富来源的人脐带间充质干细胞（hUC-MSCs）促进大鼠损伤脊髓功能恢复主要通过分泌神经营养因子起作用，而新生神经纤维少量增加，胶质瘢痕部分抑制。还发现姜黄素拮抗脊髓损伤后前炎症因子作用保护脊髓，并减轻胶质瘢痕形成。促使移植细胞分化参与神经通路构成是脊髓修复的新策略，须克服胶质瘢痕的阻碍。姜黄素具有强烈调节组蛋白乙酰化功能，组蛋白乙酰化在各种干细胞增殖分化中起重要作用。推测姜黄素可能通过该作用，促进hUC-MSCs向胶质细胞分化少，向神经细胞分化多。拟经过体外实验，结合损伤立即给予姜黄素并1周后的hUC-MSCs移植，利用组织学、免疫荧光、染色体沉淀、RNA干扰、神经束路追踪等技术，证明两者协同显著抑制胶质瘢痕；进一步阐明姜黄素的组蛋白乙酰化修饰可能的JAK/STAT和Wnt/β-catenin信号传导途径；从而为促进损伤脊髓功能的明显恢复提供实验依据。

hUC-MSCs(human umbilical cord-derived mesenchymal stem cells) with a abundant source was found to enhance the injured spinal cord funtcion of rats by secreting neurotrophins and increase neural fiber mildly,decrease the formation of glial scar partly. We also found that curcumin protect injured spinal cord by decreasing pro-inflammatory factor and formation of glial scar.The new strategy of spinal cord repair is to make grafted cell differentiate into neuron which take part in neural pathway,the neurite regrowth must get over the obstacle of glial scar.It is presumed that curcumin promote hUC-MSCs differentiate into more neuron and less glial cell owing to its intensive regulating effect of histone acetylation. So the experiment is designed to prove curcumin cooperating with hUC-MSCs may decrease glial scar and make clear likely JAK/STAT and Wnt/β-catenin signal pathway through modification effect of histone acetylation by histology, immunofluorescence, CHIP，RNA interference, neural tracing etc. it may provide experimental evidence for favor of neurogenesis and glial scar decreasing and recovery of injuried spinal cord following cell transplantation.