轴手性结构是一些催化剂和配体的优势骨架，表现出了独特的立体诱导特性，其结构还广泛地存在于天然产物以及具重要生理活性的化合物之中。传统构建轴手性的方法往往通过二芳基金属中间体还原消除得到，形成轴手性是在最后步骤，该过程中大位阻的芳烃不利偶联，同时立体选择性受取代基的影响大。.基于这些问题，我们提出先构建“具轴手性结构的活性金属中间体”然后参与后面的偶联反应的策略。我们拟通过联芳基并环化合物的开环反应来构建具轴手性结构的金属有机中间体，包括碳-碳、碳-硅键的选择性切断与重组。研究拟依靠“扭转张力”促进的开环来活化环状硅化合物、9H-芴醇和9,10-菲二酮及其衍生物的碳-硅、碳-碳键。我们将进一步研究非对称9H-芴醇选择的性开环，实现从中心手性到轴手性的转移，同时探索轴手性高分子的合成并研究其圆偏振光发色等性能。

Axially chirality is one of the most important ways for molecules to demonstrate their three-dimensional structure. It widely exists in natural products and bioactive molecules. It becomes one of prior skeletons for chiral ligands or catalysts in asymmetric catalysis. In the classic coupling reactions, the axial chirality is constructed via the reductive elimination of bis(aryl)metallic intermediates. It is usually difficult to construct atropisomers due to its requirement of a highly sterically bulky environment around the axis. Furthermore, the outcomes of the reaction were usually affected by the substituents. . Based on these problems, we are going to construct axially chiral organometallic intermediates before final couplings, which could undergo transfermation with various partners. This project is going to develop ring-opening methods for the preparation of axially chiral organometallic intermediates: including carbon-carbon, carbon-silicon bonds. It is proposed that the “torsional strain” would activate the carbon-carbon, carbon-silicon bonds in 9H-fluoren-9-ols, phenanthrene-9,10-diones and 5H-dibenzo[b,d]siloles. Finally, studies will also focus on the ring-opening reaction of non-symmetric 9H-fluoren-9-ol derivatives to realize the point-to-axial chirality transfer. Furthermore, this strategy is going to furthermore apply in axially chiral polymer synthesis, which is potentially useful in CPL.