联芳基轴手性化合物是手性化合物中重要的一类，其广泛地存在于天然产物、配体、催化剂和药物分子结构中。目前，虽然已有一些很出色的方法制备这类化合物，但制备（特别是在温和条件下制备）高光学纯度的、结构多样的联芳基轴手性化合物仍极具挑战性。本项目希望通过环状高碘化物的开环反应来高效制备联芳基轴手性化合物，拟通过廉价金属（Cu、Co、Fe等）/手性配体以及手性阴离子诱导两个主要策略来实现轴手性的控制。拟考察的亲核试剂包括氮亲核试剂，如苯胺、苄胺、脂肪胺等；氧亲核试剂，如羧酸、醇、酚等；膦亲核试剂，如二取代膦氧化合物；硫亲核试剂，如硫酚、硫代羧酸等。相比于已有的一些合成联芳基轴手性化合物的方法，该方法有反应条件温和、原子经济性好等优点。

Biaryl atropisomers represent an important class of chiral molecules, and they are widely present in natural products, ligands, and pharmaceutical molecules. However, the preparation of structurally diverse biaryl atropisomers under mild conditions is a significant challenge. In this proposal, we are going to prepare biaryl compounds bearing Ar-I functionality via the non-noble metal-catalyzed ring-opening reaction of cyclic diaryliodoniums. Two strategies would be adopted to realize this enantioselective transformation: non-noble metal (Cu, Co, Fe etc.)/chiral ligand system and chiral anion catalytic system. Different kinds of nucleophiles will be used in this project to test the generality of this transformation. They are N-nucleophiles (aniline, benzylamine, aliphatic)，O-nucleophiles (acids, alcohols, thiols), P-nucleophiles [HP(O)R2] and S-nucleophiles (benzenethiol, thioic acid). The merits of these proposal are of highly atom-economic and with mild conditions.