与目前研究较多的二重形状记忆高分子材料相比，三重形状记忆高分子由于更能满足复杂条件的要求，能根据需要产生复杂、积极的变形，在生物医学领域受到了研究者的越来越多的关注。本课题拟在聚己内酯二醇基础上先合成不同羧基含量的形状记忆聚氨酯和异烟酸胆甾醇酯液晶基元，再通过分子间氢键作用将高分子与液晶小分子组装得到一种能在37 ℃产生形状记忆功能且回复时间可控的具有侧链液晶结构的高分子复合材料,最后通过图形印章法在高分子复合材料薄膜表面制备微图形结构（以微沟槽和微点阵为主），将高分子材料的三重形状记忆功能引入表面微结构中,详细考察细胞在动态变化的表面基底上其功能如何变化。通过本项目的研究,期望能深入理解细胞与基底表面的相互作用机理。

In contrast to the dual-shape memory polymers, triple shape memory polymers have been attracting more and more attentions in biomedical field due to the facts that they can meet the requirements of complex conditions and can change their shape easily according to the requirements.The project will firstly synthesize shape memory polyurethane(SMPU) based on poly(ε-caprolactone) -diols with carboxyl groups and a novel liquid crystal compound with an electron-rich pyridine ring(INCh),then prepare a supramolecular liquid crystalline polymer composite with triple shape memory function at 37 ℃ by the strong H-bonding interactions between SMPU and INCh, fabricate these micropatterns including microarrays and micrograves on the surface of the polymer composite film by means of the graphical stamp method, and finally investigate the cell behaviours in detail on the surface substrate with dynamic changes, which results from the introducing of triple shape memory function of the polymer composite into the surface microstructure.Based on the study we can precisely understand the cell-substrate interaction mechanism.