以新的T细胞亚群Th22为核心的免疫调控网络在口腔扁平苔藓发病中的作用

目前公认，口腔扁平苔藓(OLP)是T细胞介导的慢性免疫相关性疾病，但其致病的T细胞亚群及其相应的作用网络未完全阐明。Th22是2009年才发现的新T细胞亚群，其与黏膜皮肤疾病的相关性受到关注，但未见其与OLP关系的报到。而本课题组前期研究提示：以Th22为核心的免疫调控网络可能通过激活JAK/STAT、MAPK等信号通路，调节OLP角质形成细胞的功能，参与OLP的发生和发展。为印证该假设，拟研究：①该免疫调控网络关键细胞和细胞因子在OLP临床样本中的表达分布规律；②该调控网络对OLP角质形成细胞增殖、凋亡、移行、分化以及炎症反应的调控作用；③该调控网络对OLP角质形成细胞的调控机制及相关的信号通路、关键调控因子。结果不仅有助于发现Th22与OLP的关系，更重要的是，利用OLP作为观测模型，进一步阐明Th22这一新细胞亚群与人类黏膜免疫与疾病的关系，并为寻找相关疾病的防治新靶点提供依据。

Oral lichen planus(OLP) is a T cell-mediated immune-related disease. The etiology and pathogenesis of OLP have not been well elucidated. The newly discovered T helper cell subset, Th22, has played an important role in the pathogenesis of several epithelial immune-related diseases. According to the results of previous studies of our group and recent advance in this research field, we made a hypothesis that Th22 cell and its related cytokines might have participated in the pathogenesisi of OLP through the activation of JAK/STAT、MAPK and other signal pathways. The following studies are designed to prove that hypothesis: ①Expression and distribution of Th22 cell and its related cytokines in the clinical samples of OLP; ②The role of Th22 cell and its effector cytokines on the proliferation, apoptosis, migration, differentiation and inflammation of oral keratinocytes and the possible signal pathways. The result of this research will shed a new light on the mechanism of interations between T lymphocytes and oral keratinocytes in the pathogenesis of OLP, thus facilitate the development of new therapeutic strategies to treat and prevent OLP and other chronic immune-related diseases.