功能磁共振（fMRI）结合大脑白质纤维束示踪技术（DTT）能够可视化显示出大脑皮层功能区及白质纤维束的分布，该技术已经广泛应用于基础研究和临床应用。但在临床实践中，如何在众多纤维束中显示出特定传导束、以及如何降低高侵袭性肿瘤对显像准确性的影响，已经成为影响DTT技术进一步临床应用的瓶颈问题。我们在前期临床研究的基础上将围绕如下问题开展研究：如何应用DTT技术对高侵袭性肿瘤影响下的运动传导束进行显像？如何在病变情况下选取种子点？如何检验其准确性和可靠性？为此，我们在建立大鼠脑胶质瘤模型后行磁共振扫描，并行病理检测，将影像学指标与病理观察结果进行对比，论证如何在侵袭性肿瘤影响下对种子点进行选取，进而克服无法对临床病人进行有创性检查的难题，论证DTT技术的可靠性。为制定有效的手术方案，改善患者术后生存质量提供依据，且为DTT技术与无任务静息条件下和有任务下脑功能磁共振影像的融合提供理论基础

fMRI combined with diffusion tensor imaging tractography(DTT) can illustrate the functional areas and the distribution of major tracts in brain,and the technology has been wiedly used in the basic research and clinical experience.However,it is important for a surgeon to distinguish some specific tracts from fiber bundles and increase the preciseness of tracts imaging by the influnence of malignant tumor,which has become an obstruction of the further application of DTT.The basis of our research will be carry out around the following questions:How to show the motor tracts influenced by malignant tumor?How to select a seed target around the lesions?How to verify the accuracy and reliability of this technology? Therefore,we will establish a C6 rat glioma model,then MRI scan and pathological examination will be done and compared each other.By this way,the former questions will be sovled and surgeons can have a effective plan for a patient to enhance patients' postoperative quality of life.Furthermore,our research will contribute to the developing of DTT combined with the tasking state or resting state of functional magnetic resonance imaging.