2型糖尿病（T2DM）属于慢性、终生性代谢疾病。目前医学水平尚无法根治，只能通过各种方法控制血糖、延缓并发症的发生，因此“预防”依然是降低T2DM患病率的关键。饮食方式被普遍认为与T2DM的发生密切相关，饮食不当会导致生物节律紊乱，这一过程又受到多种基因的调节。明确不同饮食方式的作用，对预防T2DM的发生至关重要。但是目前关于饮食与T2DM关系的流行病学资料和人群实验的证据较少。.连续高频的摄食会导致“持续性餐后状态”——即摄食间隔时间较短，血糖尚未恢复，又进行二次摄食，且每日这种状态持续时间超过12小时。这种“持续性餐后状态”是否会导致器官的生物节律改变，进而引起T2DM尚需要证实。本文拟采用双向队列研究阐明“持续性餐后状态”与T2DM的因果关系，再用人群实验探测“持续性餐后状态”下人体的代谢以及生物节律信号的变化，并利用动物实验证实“持续性餐后状态”导致T2DM发生的可能性及其机制。

Type 2 diabetes mellitus (T2DM) is a chronic and lifelong metabolic disease. It is not curable now but treatment can extend a patient's life by reducing his blood glucose and incidence of the complications. T2DM is strongly linked with diet mode. Improper diet will lead to the disturbances in chronobiologic rhythms which are regulated by various genes. It is the key to clear the mechanism of diet on T2DM for reducing its incidence. However, there are less epidemiological data and human evidence about the relationship between diet and T2DM. .Continuous eating with high frequency will lead to persistent postprandial state. That is to say, people eat with a short interval and without recovery of blood glucose over more than 12 hours. It has not been evaluated whether persistent postprandial state will lead to changes in biological rhythm. This project attempts to illustrate the causal relationship between persistent postprandial state and T2DM by biphasic cohort study, to observe changes of tissue metabolism and signals of circadian clock, and to confirm the incidence for T2DM and its mechanism.