LincRNAs在EMT转化及肿瘤迁移侵袭过程中起重要调控作用。前期通过GEO数据库外显子测序结果ncRNA注释二次分析，共获得胃癌差异表达7个lincRNAs，其中PART1在胃癌组织中表达显著下调，其低表达与胃癌术后远处转移及总生存期较短相关。PART1过表达后能抑制MCG-803细胞TGF-β/Smad信号通路及其介导的EMT转化，并使细胞体外生长、克隆形成、迁移侵袭、体内致瘤和转移能力下降。而干扰PART1表达则明显促进AGS细胞TGF-β/Smad信号通路及细胞EMT表型、促进胃癌细胞生长和转移等恶性生物学行为。PART1可以与eEF1A、ATP5B、RPL5和PCNA等肿瘤相关蛋白分子结合，发挥对胃癌细胞EMT转化及胃癌转移的调控作用。本研究拟在这些工作基础上，深入探讨PART1在调控EMT诱导胃癌转移中的作用和调变机制及PART1自身表达调控因素，为胃癌预后和治疗提供依据。

LincRNAs play an important role in the regulation of EMT and tumor metastasis. In our previous work, we identified 7 lncRNAs that were differentially expressed in gastric cancer by GEO database reanalysis. PART1 was identified as significant down-regulated lincRNA in gastric cancer tissues, and its low expression was correlated with the postoperative metastasis and short overall survival time of patients. Overexpression of PART1 could inhibit the TGF-β/Smad signaling pathway and mediated EMT of MCG-803 cells, and decreased cell growth, clone formation, migration and invasion, tumorigenisis and tumor metastasis. The interference of PART1 expression can significantly promote not only TGF-β/Smad signaling pathway and EMT phenotype of AGS cells, but also the cell malignant biological behavior, including growth and metastasis of gastric cancer cells. PART1 can be combined with tumor associated proteins, such as eEF1A, ATP5B, RPL5 and PCNA, which play a key role in the regulation of EMT and EMT-mediated metastasis in gastric cancer cells. On the basis of these findings, in this study, the role of PART1 in the regulation of EMT induced metastasis and the regulation mechanism of PART1 expression were further determined, to provide a clue for prognosis and treatment of gastric cancer.