共轭氮宾由于轨道的相互作用可以展现为1,3-偶极体的反应性。这些活性中间体非常活泼，其反应选择性往往比较差。过渡金属的许多优良特性使得这一类共轭金属氮宾的反应具有高选择性，条件温和等特点。从相应的氮宾前体出发，在过渡金属的存在下现场生成金属氮宾/1,3-偶极体，并用合适的亲偶极体比如烯烃和炔烃对这些中间体进行现场捕获，可以高效的构筑五元含氮杂环比如吡咯/啉、咪唑/啉、噁唑/啉、噻唑/啉等。这一类新的【3+2】环加成方法学的发展将不但丰富了金属氮宾化学，加深对这一类反应中间体的理解，也会为药物合成提供新的合成策略。也即该项目的实施既有学术意义具有实用价值。

Conjugated nitrene due to the interaction of pi orbital and p orbital of Nitrogen, could exhibit 1,3-dipole nature. Usually, these nitrene intermediates are too reactive and show poor selectivities in reactions. Transition metals have lots of excellent properties, and should render the conjugated metal nitrene reaction highly selective and under mild conditions. From proper nitrene precursor, under the help of organic metal, conjugated metal nitrene could be generated and intercepted in situ by alkene or alkyne to give five membered azo-rings such as pyrole/pyroline, imidazole/imidazoline, oxazole/oxazoline, thiazole/thiazoline and so on. These would address the problems encounter by conjugated nitrenes. These new [3+2] cycloaddition reactions will not only enrich the nitrene chemistry and our understanding of these reactive intermediates, but also provide new strategies for medicinal synthesis. So this program is highly valuable in terms of both academic and industry.