益生菌干预对腹泻羔羊胃肠道内容物和黏膜菌群及肠黏膜免疫调控作用的研究

肠道菌群失衡导致的微生态失调是羔羊（犊牛）发生腹泻的重要原因。至今，新生羔羊、犊牛腹泻的防治在牛羊生产中依然是一个难题。本项目在已完成的国家自然科学基金项目基础上，以羔羊为试验模型，研究益生菌干预对健康羔羊胃肠道内容物和黏膜菌群及肠黏膜免疫的影响，进一步研究益生菌干预对腹泻羔羊胃肠道内容物和黏膜菌群结构模式及肠道黏膜免疫的调控作用。项目将从胃肠道菌群特征模式变化认识羔羊发生腹泻的详细微生态调控机理，从调控羔羊胃肠道群特征模式及肠黏膜免疫机能角度揭示益生菌的可能的“益生”机制。本项目的研究将丰富羔羊胃肠微生态理论，为通过益生菌调控腹泻羔羊胃肠道菌群结构和黏膜免疫调控、保证幼龄羔羊健康生长提供科学依据和理论指导。

Gut microbiota dysbiosis caused by microflora imbalance is an important cause of the lamb (calf) occurrence of diarrhea. So far, the prevention and treatment of diarrhea of newborn lambs, calves in production practice is still a problem. The project is basis on completed National Natural Science Foundation, lambs as experimental model to study the structure pattern of gastrointestinal and mucosal microbiota. Further research is conducted on effects of regulation of probiotics intervention on gastrointestinal and mucosal microbiota and intestinal mucosal immunity of diarrhea lamb. The project will help us to understand the detailed mechanism of neonatal ruminant diarrhea through the change of mucosal microbiota structure, and reveal possible “probiotic” mechanism from the regulation of gastrointestinal microbiota and mucosal immune. This project will enrich the theory of lamb gastrointestinal microflora, provide a scientific basis and theoretical guidance for lambs by using probiotics to regulate gastrointestinal microbiota and the mucosal immune, ensure young lamb (calf) healthy growth.