周边光学信号被发现与近视进展相关。光学信号涉及屈光度（离焦、散光）和视网膜像质（像差、散射和衍射）两层概念。仅改变周边离焦能显著延缓动物近视进展，在人类仅获部分成功，提示人眼周边光学信号如散光、像差和衍射等可能在矫正离焦后突显，影响了周边视网膜像质并导致人类近视进展。申请者最近研究发现，我国中原地区儿童的周边屈光度与其他人种相比模式相似幅度较小。是否周边视网膜像质主要影响了我国儿童的近视进展？本项目拟（1）采用光学软件建立基于周边屈光度的儿童眼光学模型，随访儿童3年并根据屈光变化值逐步优化模型；(2)由光学模型经傅里叶转换获得不同个体在不同光波长、视场角和瞳孔大小下的周边视网膜像质（点扩散函数、调制传递函数和斯特列尔比），明确上述因素对周边视网膜像质的影响程度；(3)综合评估周边视网膜像质的变化趋势及其在校正儿童近距离视负荷和户外活动时间后对近视进展的影响，为近视的干预治疗提供理论依据。

Peripheral optical components have been found to be associated with myopia progression. Peripheral optical components involve two concepts, refraction (defocus and astigmatism) and retinal image quality (aberration, scatter and diffraction). Change in peripheral defocus alone can significantly slow myopia progression in animals, but has obtained only partial success in humans. This suggests that peripheral optical components such as astigmatism, aberration and diffraction in humans might be prominent after the correction of defocus, then affect peripheral retinal image quality, and finally influence myopia progression in humans. The applicant has recently found that the peripheral refractions of children in central China have similar patterns, but lower magnitudes as those of other races. Does peripheral retinal image quality mainly influence the myopia progression in Chinese children? In this project, the applicant plans to (1) use optical software to establish optical models of children based on peripheral refraction, to follow up these children annually for 3 years and then optimize the optical models based on changes in refraction. (2) With these optical models and Fourier transformation, retinal image quality (point spread function, modulation transfer function, and Strehl ratio) at different optical wavelengths, field angles and pupil sizes can be obtained. The influences of these factors on peripheral retinal image quality could be identified.(3) evaluate the variation tendency of peripheral retinal image quality and their effects on myopia progression after adjusting of near work visual load and time spent in outdoor activities in children, then provide theoretical basis for intervention strategies for myopia.