转录因子Foxo1(Forkhead box o 1)在调节机体代谢、组织发育、细胞周期和凋亡等多种过程中发挥关键作用。近几年研究发现，Foxo1 也参与对免疫细胞迁移及功能的调控。NKT细胞是一类固有样T淋巴细胞，是连接天然免疫和获得性免疫的桥梁，在感染、代谢性疾病、自身免疫性疾病和肿瘤中都发挥了重要作用。但是，Foxo1对NKT细胞发育和功能的调控作用目前尚未报道。我们在前期研究中发现，肿瘤组织中NKT细胞的Foxo1表达下调，且与NKT细胞功能异常有关，我们拟利用NKT细胞特异性Foxo1敲除小鼠，研究转录因子Foxo1调控NKT细胞发育分化和抗肿瘤功能的分子机制，为肿瘤治疗提供新的思路。

Foxo1 (Forkhead box o 1) is a transcription factor, which regulates metabolism, tissue development, cell cycle, and apoptosis. Interestingly, recent studies have shown that Foxo1 regulates the migration and functions of immune cells as well. Natural killer T (NKT) cells are innate-like lymphocytes and bridge the innate and adaptive immune systems. It is well known that NKT cells play important roles in infection diseases, metabolic diseases, autoimmune diseases, and tumors. It is still unclear whether Foxo1 controls development and functions of NKT cells. Our previous study showed that down-regulation of Foxo1 in NKT cells was associated with its dysfunction in tumors. Using Foxo1 conditional knockout mice, we will demonstrate the mechanisms by which Foxo1 regulates the development and anti-tumor functions of NKT cells. Our work will provide new ideas for anti-tumor therapies.