牙颌畸形为口腔常见病，通过正畸治疗可对牙齿位置进行矫正。如何在术前准确预测牙齿的移动和牙槽骨的反应，对于临床治疗具有重要的指导意义。在矫治载荷作用下，初始阶段的牙齿机械性移动与变形已经可用有限元计算进行分析，而继发阶段的牙周组织改建则必须结合牙槽骨的骨塑建和重建机制进行分析。目前，已经有国内外学者针对正畸牙移动过程进行了模拟预测；申请人在先期研究中也提出相应算法，初步模拟了此正畸过程。但是，现有模型缺乏针对性的实验验证和充分的科学依据。据此，本项目的研究目标就是通过建立动物实验模型，验证现有牙移动模拟结果，深入探究矫治力与牙移动速率的非线性对应关系，对骨塑建和重建算法的调控参数进行限定，从而推动正畸牙移动预测的进一步发展。本研究中拟对大鼠的前后牙分别施加不同大小的矫治力，然后利用微观计算机断层扫描和荧光染色组织学检验的方法定期对牙齿、牙槽骨和牙周膜进行定量分析，拟合数据并推导完善理论方程。

Malocclusion is a common oral disease, and tooth position can be corrected by orthodontic treatment. How to predict exactly the movement of tooth and the change of alveolar bone is very significant for the clinical treatment. Under the treatment load, during the initial stage, tooth movement and mechanical deformation can be studied by numerical simulation approaches, such as the Finite Element Method. But during the secondary phase, the analysis and forecasting of periodontal tissues reconstruction have to be combined with alveolar bone modeling and remodeling mechanism. At present, several studies have been executed to reproduce the process of tooth movement. In our previous study, the algorithm for orthodontic tooth movement based on biomechanical mechanisms has been also proposed, and the orthodontic treatment has been simulated. However, this model lacks targeted experimental verification and adequate scientific basis. Accordingly, the objective of this project is to establish animal models to validate the existing simulation results of tooth movement, to research the nonlinear relationship between orthodontic force and tooth movement rate, and to limit the range of bone modeling and remodeling parameters. This study intends to apply orthodontic force on the anterior and posterior teeth of rats, producing translational and rotational movement. Then, the micro-computed tomography and histological staining methods will be used to test regularly rat teeth, alveolar bone and periodontal ligament, and this quantitative analysis will be applied to fit the data and derive the theoretical formulas. In this study, it is hoped to promote the further development of numerical prediction of orthodontic tooth movement.