微结构拓扑变化调控下颌骨重建支架力学适配性的研究

多种病因均可导致下颌骨节段性缺损，将影响咀嚼、吞咽等重要生理机能，其功能性重建仍然是个挑战。利用3D打印网状支架再结合植骨材料的混凝土式修复可望解决该难题，而支架与宿主骨之间良好的生物力学适配性尤为重要。项目组前期就支架微结构拓扑构型的生物力学影响进行了研究，认为特定受力环境下微结构与宿主骨之间的力学调控机制还不甚明了。为此，申请人基于“力学调控系统”原理提出了影响微结构力学适配性的科学假设，并在前期研究基础上，构建相应数值模型和动物模型，利用生物力学和力生物学的技术手段，设计了3部分研究内容来验证假设：1）基于骨功能适应性理论模拟微结构间骨长入和重建；2）结合仿真和动物试验分析微结构拓扑构型变化；3）生理负载下分析下颌骨重建网状支架的力学适配性。本项目通过探讨微结构适配性的力学调控机制，可为骨缺损修复三维网状支架的力学优化提供理论依据和设计准则，对下颌骨缺损的功能性重建具有重要研究意义。

Many causes can lead to segmental mandibular defects, which will affect mastication, swallowing and other important physiological functions, but its functional reconstruction is still a challenge. It is possible to solve this problem by using 3D printing 3D mesh metal scaffold combined with bone graft material in the mode of concrete, and excellent biomechanical adaptability between the scaffold and host bone is particularly important. In the previous study, the biomechanical effects of the topological configuration of the scaffold microstructure were studied, but the mechanism of mechanical regulation between microstructures and host bones under specific mechnical conditions is still unclear. For this reason, based on the principle of "Mechanostat", the applicant proposes a hypothesis that affect the mechanical adaptability of microstructure. On the basis of previous research, the corresponding numerical model and animal model are constructed, and three parts of research contents are designed to verify the hypothesis by using the technical means of biomechanics and mechanobiology. 1)Simulation of bone growth and remodeling between microstructures based on bone functional adaptability theory; 2)Study on topological configuration change of microstructure in combination of simulation and animal experiment; 3)Analysis of mechanical adaptability of mandibular reconstructive mesh scaffolds under physiological loading. This project can provide the theoretical basis and design criterion for the mechanical optimization of 3D mesh scaffold for bone defect repair by exploring the mechanism of mechanical regulation of microstructure adaptation. It is important to study the functional reconstruction of mandibular defect.