多孔生物陶瓷颗粒诱导颌骨缺损重建的跨尺度生物力学研究

口腔种植修复中，复杂骨增量手术一直是种植外科最具挑战的难题。为了解决传统钛网技术并发症高的问题，申请人前期创新提出采用3D打印定制化三维网状支架临床方案。经过多年探索，植入物暴露率已从传统方法的28~63%降低到约10%，但尚需进一步降低。申请人研究发现，暴露的主要原因是现有植骨颗粒在软组织侵入下会发生特定形变，既无法长期保证成骨空间稳定，也无法保证血管化所需孔隙结构，其生物力学特性难以满足临床要求。基于此，申请人提出精准构筑一套多级孔道生物陶瓷颗粒材料体系，使其同时具备成骨空间维持能力和微流场介质传输能力。申请人拟引入力生物学调控算法和材料降解控制算法，基于计算流体力学和孔压耦合单元模型，跨尺度对生物陶瓷颗粒的胞元、单体、堆集进行系统研究，通过动物模型验证仿真结果。本项目力求探明提高生物陶瓷颗粒性能的生物力学规律，以期为临床提供一套行之有效的解决方案，研究课题具备重要学术价值和临床意义。

Complex bone augmentation surgery has always been the most challenging problem in dental implantation prosthodontics. In order to solve the problem of high complication of traditional titanium mesh technology, the applicant innovated and proposed a clinical scheme of using 3D printing customized three-dimensional scaffold in the early stage. After years of exploration, the implant exposure rate has been reduced from 28~63% in traditional methods to approximately 10%, but further reduction is still necessary. According to the applicant's research, the main reason for the exposure is that the existing bone graft particles undergo specific deformation under the invasion of soft tissue, which can neither guarantee the long-term stability of osteogenesis space nor guarantee the pore structure required for vascularization, and its biomechanical characteristics are difficult to meet the clinical requirements. Based on this, it is proposed to accurately construct a set of hierarchical porous bioceramics granule material system, so that it has both the osteogenic space maintenance capacity and the medium transmission capacity of microflow field.The applicant intends to apply the mechanobiological regulation algorithm and the material biodegradation control algorithm, based on the computational fluid dynamics model and the coupled pore-pressure element model, to systematically investigate the cell-element, monomer and collection of bioceramics granules across scales, and then verify the simulation results through the animal model. The objective of this project is to explore the biomechanical characteristics that can improve the performance of bioceramics particles, and to provide a set of effective solutions for clinical practice. The research topic has important academic value and clinical significance.