与当今生态文明建设相适应，农药的创制必须以生态友好为前提，寻找新作用机制、高效和环境安全的杀虫剂显得尤为迫切。在前面已经结题自然科学基金项目取得的研究成果基础之上，本项目将采用化学与生物学相结合的方法，结合JH合成抑制领域的最新研究成果，主要围绕最新发现的具有农用杀虫活性的模拟肽化合物P5，将进一步深入开展高活性模拟肽的化学生物学和新型小分子模拟肽类农药的创新研究。主要内容包括三个方面：1）模拟肽先导化学结构多样性研究，2）P5等高活性化合物的作用谱及生态安全性研究， 3)高活性化合物的作用机制研究。通过本项目研究，期望为模拟肽类新农药创制提供重要的理论指导，力争为IGRs的创制开辟出一片新的领域，为绿色植保提供高效安全的新策略。

Adapt to the construction of ecological civilization，new pesticides must be discovered on the basis of eco-friendliness. Thus, it is particularly urgent to find new insecticides with novel mechanisms, high efficiency as well as environmental safety. Based on our preliminary positive results, this project will continue to find new peptide mimetic IGRs considering both chemical optimization and biological mechanism of active AST mimic P5, using a combination method of chemistry and biology and the latest research results in JH synthesis inhibition. The story include three parts as follows: 1）The chemical optimization of high active compound P5, discovered in our former work, with the method of peptidomimatics and pesticide molecular design to find new perspective IGRs candidates; 2）The study on insecticidal spectrum and eco-toxicity of peptide mimic P5 etc；3）the biological mechanism of high active P5 studied with the techniques of molecular docking and molecular biology. The results will be useful for further discovery of new IGRs, and meaningful to provide important theoretical guidance to new pesticide discovery and new potential approach for green plant protection.