造血干/祖细胞（HSC/HPC）衰老与机体衰老和老年性疾病发生密切相关。我们研究证明：人参皂苷Rg1具有抗氧化和抗辐射损伤作用、能有效延缓HSC/HPC衰老，减缓HSC/HPC端粒缩短和增强端粒酶活性，但Rg1延缓HSC/HPC衰老的靶向调控分子仍有待深入研究。最新研究表明SIRT6通过抑制NF-κB调控有机体细胞的衰老。迄今SIRT6与NF-κB对话在人参皂苷Rg1延缓HSC/HPC衰老及HSC/HPC衰老中作用还未见报道。本课题将现代干细胞最新的研究技术与祖国传统医学的抗衰老理论和对干细胞的认识结合起来，探讨衰老调控因子SIRT6与NF-κB对话在Rg1延缓HSC/HPC衰老中的作用。课题对阐释Rg1对HSC衰老的调控机理有重要理论贡献；对通过"补气"途径调控干细胞衰老和防治老年性疾病有重要应用价值；对干细胞衰老机理研究提供可借鉴的新思路与新方法。

Hematopoietic stem cell and progenitor cell(HSC/HPC) aging is closely related to organism aging and kinds of senile diseases. Our previous study demonstrated that ginsenoside Rg1 have the effection of antioxidation and radioresistance. It can efficiently delay HSC/HPC senescence through weaken the telomere shorten and strengthen telomerase activity, but the target regulate element in Rg1 delay HSC/HPC senescence need intensive study. The lasted study indicated that SIRT6 can inhibit NF-κB to regulate organism cell senescence. It has not seen report about the effect of SIRT6 interact NF-κB in ginsenoside Rg1 to delay HSC/HPC senescence. In this study, it takes the latest techniques of stem cell closely integrated with the anti-aging theory and the stem cell knowledge of traditional medicine, investigating the effect of SIRT6 interact NF-κB in ginsenoside Rg1 to delay HSC/HPC senescence. The study aimed to contribute the mechanism of ginsenoside Rg1 regulate HSC/HPC senescence, and provide the application value to regulate stem cell senescence and prevente senium disease. It also provide the new thinking and the new method to the study of stem cell senescence.