慢性高眼压是慢性青光眼发生发展的主要原因，持续有效地降低眼压是目前阻止和延缓青光眼病情进展的唯一有效措施。而临床上发现，许多青光眼患者眼压控制在正常范围后，视神经结构改变及功能损伤仍然存在，相同眼压下不同患者的病情进展存在较大差异，其原因尚未阐明。研究证实组织的生物力学特征可以反映其结构和功能的关系。申请人前期利用有限元建模分析方法发现，眼球后部巩膜生物力学特征对眼压作用最为重要，然而其作用的区域性差异、巩膜筛板间作用关系及生物力学特征改变原因等问题尚待研究。在此基础上，本课题拟从生物力学、眼科学和病理学等学科交叉的角度研究慢性高眼压和正常眼压眼巩膜及筛板各区域生物力学特征差异以及在眼压作用下的变化规律，并寻找导致这些差异性变化的各种病理学因素，建立基于不同眼压的眼球有限元模型，探索青光眼视神经结构性损伤的潜在机制和规律，为临床上青光眼患者制定个体化目标眼压和进行预后评估提供依据。

Elevated intraocular pressure (IOP) is the main cause for the development of chronic glaucoma. Continuous and effective reduction of IOP is the effective measure to prevent and delay the progression of glaucoma. But clinical studies have found that changes of structure and function of optic nerve still persist after IOP controlled, and progress of the disease existed individual differences under same IOP. The reasons have not been clarified. The biomechanical properties of tissues can reflect the relationship between their structure and function. The applicant's previous study using finite element modeling found that reaction to high IOP in the posterior sclera is most important. However, the role of regional differences and mechanical relationships between sclera and lamina cribrosa (LC) and reasons of mechanical change still remain to be studied. The aim of this study is to explore the difference of biomechanical characteristics and change regulation in multiple regions of sclera and LC between chronical high IOP and normal IOP from biomechanics, ophthalmology, and pathology .Finding out the reasons for these changes and Exploring the potential mechanism in the process of chronic glaucoma, establishing the finite element model of eyeball based on different intraocular pressure. We hope to provide theoretical basis for glaucoma patients about personalized target IOP and prognosis assessment.