Elevated IOP Alters the Material Properties of Sclera and Lamina Cribrosa in Monkeys.
Elevated IOP Alters the Material Properties of Sclera and Lamina Cribrosa in Monkeys.
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作者：
眼内压（IOP）升高对慢性青光眼进展的不同阶段有显着影响。在这项研究中，我们研究了眼压升高的非人灵长类动物模型中巩膜和筛板 (LC) 材料特性的变化。 选择正常成年藏猕猴构建高眼压模型。高眼压稳定维持40天后，取双眼眼球用于眼球宏观参数的测量。沿周向和轴向获取后巩膜组织条，并分别测量厚度。通过应力松弛、蠕变和拉伸测试获得生物力学参数。对 LC 和视神经乳头 (ONH) 周围的巩膜组织进行纳米压痕测试以获得压缩模量。 在眼压升高的情况下，实验组眼球轴径变化大于横径变化，ONH周围平均巩膜厚度小于对照组。实验组巩膜弹性模量和应力松弛模量均大于对照组，蠕变速率低于对照组。对照组圆周巩膜轴向弹性模量和应力松弛模量较大，蠕变速率较小。在实验组中，两个方向的生物力学特征没有显着差异。与对照组相比，实验组LC的压缩模量较小，ONH周围巩膜的压缩模量较大。 眼压升高会改变巩膜和 LC 的粘弹性和各向异性。这些可能会导致组织对外部力量的抵抗力降低，自我恢复能力下降。
Elevated intraocular pressure (IOP) has significant impacts on different stages in the progression of chronic glaucoma. In this study, we investigated changes in the material properties of sclera and lamina cribrosa (LC) in a nonhuman primate model with elevated IOP. Normal adult Tibetan macaques were selected for the construction of elevated IOP model. After 40 days of stable maintenance on the ocular hypertension, the binocular eyeballs were obtained for the measurement of macroscopic parameters of the eyeballs. Posterior scleral tissue strips were obtained in circumferential and axial directions, and thickness was measured, respectively. Biomechanical parameters were obtained with stress relaxation, creep, and tensile test. The nanoindentation test was performed on the LC and scleral tissue around optic nerve head (ONH) to obtain compressive modulus. In the presence of elevated IOP, variations of the axial diameter of the eyeball were greater than those of the transverse diameter, and the mean scleral thickness around ONH was smaller in the experimental group than control group. The elastic modulus and stress relaxation modulus of sclera were larger, and the creep rate was lower in the experimental group than control group. In the control group, the elastic modulus and stress relaxation modulus of the circumferential sclera were larger in the axial direction, and creep rate was smaller. In the experimental group, there was no significant difference in biomechanical characteristics between the two directions. Compared to the control group, the compression modulus of the LC was smaller, and the compression modulus of sclera around ONH was larger in the experimental group. Elevated IOP alters the viscoelasticity and anisotropy of sclera and LC. These may contribute to reduction of the organizational resistance to external forces and decline in the ability of self-recovery.
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影响因子：
13.7
作者：
Tham, Yih-Chung;Li, Xiang;Cheng, Ching-Yu
通讯作者：
Cheng, Ching-Yu
DOI：
10.1139/o96-080
发表时间：
1996-01-01
期刊：
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
影响因子：
--
作者：
Chiquet, M;Matthisson, M;ChiquetEhrismann, R
通讯作者：
ChiquetEhrismann, R
DOI：
10.2147/opth.s44884
发表时间：
2013
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Usui S;Ikuno Y;Uematsu S;Morimoto Y;Yasuno Y;Otori Y
通讯作者：
Otori Y
影响因子：
4.2
作者：
HERNANDEZ, MR;ANDRZEJEWSKA, WM;NEUFELD, AH
通讯作者：
NEUFELD, AH
影响因子：
2.4
作者：
Hata, Masayuki;Hirose, Fumitaka;Kurimoto, Yasuo
通讯作者：
Kurimoto, Yasuo