小麦抗病基因发掘与高效利用是防控小麦病害的关键。本研究组前期从国内外种质中筛选出一个抗病性全面的材料Centrum，高抗条锈病和白粉病，中抗赤霉病。抗条锈病QTL初步定位结果表明，该抗源在7B染色体上具有一个成株期抗锈病主效QTL（QYrCEN.nwafu-7BL）。在此基础上，本项目整合前期构建的RIL群体和小麦SNP芯片全基因组扫描结果，以及多年多点的表型数据，进行抗病QTL定位；结合SNP芯片和KASP、STARP标记开发，着重开展抗条锈病主效QTL（QYrCEN.nwafu-7BL）精细作图研究，精确评估主效QTL抗病性的效应值，为下一步的QTL的克隆奠定基础；同时，对抗赤霉病QTL进行初定位，开发可用于辅助选择的分子标记；利用相关抗病QTL辅助选择标记，高效开展抗源转育，培育兼抗条锈病、赤霉病和白粉病的亲本材料，为加速培育优良的抗病种质资源提供技术支撑。

Discovering and utilization wheat resistance genes is a key step for durable resistance breeding. In the domestic and foreign germplasm our research group identified the Centrum is a comprehensive disease resistance cultivar which high resistance to stripe rust and powdery mildew, at the same time it performances a moderate resistance to Fusarium graminearum. This project is based on the RIL population and wheat SNP chips genome-wide screen, and phenotypic data evaluated with disease collected from multi-point for many years to map the QTLs confers disease resistance. Combine variety of phenotypic data, SNP array and KASP marker, developing markers for fine mapping and molecular marker assisted selection. Though the secondary population construction achieves the major QTL (QYrCEN.nwafu-7BL) fine mapping, accurate assessment of the effect of QTLs which will lay a foundation for the next step of QTLs cloning. At the same time, primary mapping the QTLs resistance to Fusarium graminearum and developing the molecular markers for assisted selection. Using the assist selection markers carry out the resistance breeding to stripe rust, Fusarium graminearum and powdery mildew.