血管紧张素1-7（Ang-(1-7)）是肾素-血管紧张素系统(RAS)家族中的新成员，其在心血管疾病的发生发展过程中发挥重要作用。最近，许多研究发现Ang-(1-7)是一种新的内源性抗炎因子，其在多种疾病的病理过程中均起到抗炎作用。瘤壁炎症在腹主动脉瘤的形成、进展及破裂的整个病理过程中均发挥重要作用。我们的预实验发现Ang-(1-7)能够显著抑制瘤壁的炎症反应，并能够抑制AAA的进展，但其作用及相关机制还需进一步深入研究。为了验证Ang-(1-7)的作用，我们将通过人体标本、动物模型及体外细胞培养等方面，采用药物干预、基因敲除、组织染色、蛋白印迹、PCR等方法，从人体、动物及细胞水平探讨Ang-(1-7)在腹主动脉瘤病理、生理过程中的作用，明确其作用及相关分子机制。本项目将为临床寻找治疗腹主动脉瘤的药物提供新思路。

Angiotensin 1-7 (Ang-(1-7)),is a new member of the renin-angiotensin system (RAS) family and plays an important role in the development of cardiovascular disease. Ang-(1-7) is a new endogenous anti-inflammatory factor, which performs anti-inflammatory effects in the pathogenesis of various diseases. Aortic mural inflammation plays an important role in the formation, progression and rupture of abdominal aortic aneurysm. Our preliminary experiment found that Ang-(1-7) can significantly reduce the mural inflammation and can significantly inhibit the AAA development, but its role and mechanism still need further study. To explore the role and mechanisms of Ang - (1-7) on the pathological and physiological process of abdominal aortic aneurysm, we will test the Human specimen, animal models and cell culture, using drug intervention, gene knockout, IHC, WB, PCR and so on. This research will provide new avenue for the clinical research of drugs for abdominal aortic aneurysm.