原位成型的粘附性仿生抗菌水凝胶在伤口愈合领域应用的研究

原位成型水凝胶作为一种独特的智能型三维网状材料被广泛应用于药物传递，组织工程和再生医学。然而，传统的原位成型水凝胶存在生物相容性差，成胶速度慢，降解时间不可控，生物粘附性不足等问题。本项目拟从分子设计角度出发，开发新型环境敏感水凝胶材料的合成和制备方法；开展高分子微观分子结构与水凝胶物理和化学性能关系等关键科学问题的研究；解决传统水凝胶材料成胶后强度较低，降解时间不可控和生物粘附性不足等传统难题；探索苯磺酰胺在水凝胶材料中的抗菌机制；验证包覆有促进伤口愈合成分的水凝胶材料在促进皮肤愈合方面的可行性，为实现高效安全的伤口愈合提供方案。这项研究不仅有助于了解水凝胶材料的形成机理和性能，也为皮肤再生提供了新的思路。因此，本项目的研究成果具有科学和应用的双重意义。

As unique and intelligent 3D-network materials, in situ-forming hydrogels have been widely used in drug delivery, tissue engineering and regenerative medicine. However, traditional in situ-forming hydrogels have some problems such as poor biocompatibility, slow gelling rate, uncontrollable degradation time and insufficient bio-adhesion. In this project, we will conduct research in (1) synthesis and fabrication of novel stimuli-sensitive hydrogels; investigation of relationships of polymer structures and hydrogel properties, and some others; (2) solve problems related to low mechanical properties, uncontrollable degradation and insufficient bio-adhesion; (3) explore the mechanism of the antibacterial of benzene sulfonamide in the hydrogel materials; (4) verify the feasibility of using drug-loaded hydrogels in wound healing, and provide solutions in efficient and safe wound healing. This study is helpful to understand the properties of the hydrogels as well as the mechanism of hydrogel formation and provides a new vision of skin regeneration. This study will be of great importance in both academic research and real application.