随着医药产业的发展，对单一手性药物对映体的需求越来越大。针对传统手性液-液萃取中萃取剂和手性选择剂回收难等问题，本项目拟构建新型环境响应型双水相体系应用于手性药物对映体拆分。在拟构建的双水相体系中，上相由一种环糊精修饰的环境响应型聚合物构成，使其既作为成相组分又作为手性选择剂；下相由另一种环境响应型聚合物构成。另在体系中加入手性离子液体修饰的磁性纳米粒子，该磁响应的粒子既具有手性识别能力又能促进相分离，并可通过外加磁场回收。相分离后所有成相组分可以通过改变环境条件（温度、pH、光照）实现聚合物的回收。实验拟设计双水相体系上、下相对两种不同构型对映体分别产生识别作用，从而实现双相协同作用完成对映体的分离。拟研究整个萃取拆分过程机理，包括热力学、动力学、各种作用力和手性选择剂与对映体作用的微观形态等。本实验设计的环境响应型双水相体系具有简单、高效、可回收等优点，在手性拆分领域具有较大应用潜力。

The demand of obtaining the single enantiomer is becoming more and more greater with the development of pharmaceutical industry. To solve the problems of difficulty recovery of the extractants and chiral selectors in the chiral liquid-liquid extraction, a serials of environmentally responsive aqueous two-phase systems (ER-ATPSs) will be prepared for the chiral separation of the chiral drugs enantiomers in this project. The phase-forming component in the top phase is a environmentally responsive polymer modified by cyclodextrin or its derivatives, this polymer can be used as both phase-forming component and chiral selector. The phase-forming component in the bottom phase is composed of the other environmentally responsive polymer. Moreover, the magnetic nanoparticles (MNPs) modified by chiral ionic liquids are added to the ATPS, which can be used as chiral selectors and improve phase separation, they can also be recycled by the magnetic field. After complete phase separation, all the components in ATPS can be recovered by changing the environmental factor, such as temperature, pH, and light. The ATPS is designed to preferentially recognize the two enantiomers in the top and bottom phase, respectively. The mechanisms in the procedures will be investigated, including the thermodynamics and dynamics, different acting forces, and the micromorphology between the chiral selectors and enantiomers. These ER-ATPSs are simple, effective, green and recyclable, which have great application potentiality in the field of chiral separation.