氧化应激在慢性牙周炎与慢性阻塞性肺疾病（COPD）相互关联机制中作用的研究

慢性阻塞性肺疾病（COPD）是一种具有高患病率和高危害性特点的常见慢性呼吸系统疾病。近期大量的流行病学研究发现慢性牙周炎与COPD紧密相关，是其发病的危险因素，但两者之间关联的具体机制仍然不清。研究表明慢性牙周炎可以引起局部和系统性氧化应激，而氧化应激是COPD最重要的发病机制。因此氧化应激可能在两者关联机制中起着重要作用。本研究通过检测慢性牙周炎大鼠及患者血液、肺部的氧化应激生物标记物水平，观测慢性牙周炎是否能够引起肺部的氧化应激并对肺组织产生损伤，并观察烟熏刺激下慢性牙周炎引起的肺部氧化应激对大鼠COPD发生的促进作用。此外，通过检测牙周干预前后COPD伴牙周炎患者血液及肺部氧化应激生物标记物水平的变化，观察牙周干预对减轻COPD伴牙周炎患者肺部氧化应激状态的作用。本研究将为牙周炎与COPD之间的关联提供进一步的证据；并为通过牙周干预进行COPD的辅助防治提供理论依据。

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high prevalence and high mortality. A strong association between chronic periodontitis and COPD has been suggested by a number of recent epidemiological studies, and chronic periodontitis is a risk factor of COPD. However, the biological mechanisms underlying these associations remain unclear. Many studies showed that chronic periodontitis could induce local and systemic oxidative stress, which is also one of the most important factors in the pathogenesis of COPD. We thus hypothesize that oxidative stress induced in chronic periodontitis patients may play an important role in the underlying mechanisms between chronic periodontitis and COPD. We propose to examine oxidative stress biomarkers in blood and lung of rats and patients with chronic periodontitis to investigate whether chronic periodontitis could induce pulmonary oxidative stress and then cause pulmonary injury. In rat models, we will investigate whether pulmonary oxidative stress induced by chronic periodontitis promotes COPD development and progression under smoking stimulation. Moreover, we will plan to conduct an intervention study in COPD patients to assess whether our periodontal intervention will lead to discernable changes in oxidative stress biomarkers in blood and lung of COPD patients with chronic periodontitis. This research will provide further evidence for the association between chronic periodontitis and COPD and serve as theoretical and empirical basis for adjuvant effectiveness of periodontal interventions for prevention and treatment of COPD.