Systemic oxidative stress biomarkers in chronic periodontitis: a meta-analysis.
Systemic oxidative stress biomarkers in chronic periodontitis: a meta-analysis.
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慢性牙周炎的全身氧化应激生物标志物：荟萃分析。
DOI：
10.1155/2014/931083
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Liu Z;Liu Y;Song Y;Zhang X;Wang S;Wang Z
氧化应激生物标志物已在慢性牙周炎患者的外周血中观察到，然而，它们与牙周炎的关联并不一致。本荟萃分析旨在阐明慢性牙周炎与体循环中氧化生物标志物之间的关系。对PubMed和Embase数据库进行电子检索，直至2014年10月，选择符合纳入标准的文章。提取牙周炎患者和牙周健康对照者外周血氧化标志物水平数据，采用随机效应模型计算标准化均数差（SMD）和95%可信区间（CI）。在31篇合格文章中，16篇有可用数据的文章被纳入荟萃分析。我们的研究结果表明，牙周炎患者的总抗氧化能力水平显着降低（SMD = −2.02; 95% CI：−3.08，−0.96; P = 0.000）和较高水平的丙二醛（SMD = 0.99; 95% CI：0.12，1.86; P = 0.026）和一氧化氮（SMD = 4.98; 95% CI：2.33，7.63; P = 0.000）。两组间的超氧化物歧化酶水平无显著差异（SMD = −1.72; 95% CI：−3.50，0.07; P = 0.059）。总之，我们的荟萃分析表明，慢性牙周炎是显着相关的三个氧化应激生物标志物的循环水平，表明慢性牙周炎在全身性疾病的作用。
Oxidative stress biomarkers have been observed in peripheral blood of chronic periodontitis patients; however, their associations with periodontitis were not consistent. This meta-analysis was performed to clarify the associations between chronic periodontitis and oxidative biomarkers in systemic circulation. Electronic searches of PubMed and Embase databases were performed until October 2014 and articles were selected to meet inclusion criteria. Data of oxidative biomarkers levels in peripheral blood of periodontitis patients and periodontal healthy controls were extracted to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) by using random-effects model. Of 31 eligible articles, 16 articles with available data were included in meta-analysis. Our results showed that periodontitis patients had significantly lower levels of total antioxidant capacity (SMD = −2.02; 95% CI: −3.08, −0.96; P = 0.000) and higher levels of malondialdehyde (SMD = 0.99; 95% CI: 0.12, 1.86; P = 0.026) and nitric oxide (SMD = 4.98; 95% CI: 2.33, 7.63; P = 0.000) than periodontal healthy control. Superoxide dismutase levels between two groups were not significantly different (SMD = −1.72; 95% CI: −3.50, 0.07; P = 0.059). In conclusion, our meta-analysis showed that chronic periodontitis is significantly associated with circulating levels of three oxidative stress biomarkers, indicating a role of chronic periodontitis in systemic diseases.
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