Celsr3在中枢神经发育中起到关键性的调控作用, 但其在小鼠视觉形成中的作用尚不清楚。研究表明Celsr3在果蝇和斑马鱼的同源基因对视觉环路的形成和视觉维持中起重要作用，我们预实验发现视网膜不同细胞Celsr3基因敲除影响了小鼠的视觉功能和视觉电生理。为此，我们提出"Celsr3基因调控小鼠视觉形成和视网膜的发育成熟"的假设，拟通过建立视网膜不同细胞Celsr3敲除动物模型，比较分析视觉行为学、电生理、视网膜细胞构筑、视觉投射、神经元突起生长及神经元突触功能等，研究结果将进一步完善Celsr3调控神经发育的理论体系，为视觉损伤修复后探索以Celsr3为靶的基因调控治疗手段奠定重要的理论依据。

Celsr3 plays key roles during neural development, but its role in the mouse visual function is still not known. It is reported that Celsr3 homologues in drosophila and zebrafish regulate the formation of visual circuits and the visual function. Our preliminary studies showed abnormalities of visual function and ERG in the mice with conditional inactivation of Celsr3 in different subgroups of retinal cells. Therefore, our hypothesis is: Celsr3 is required for the formation of visual function and the retinal maturation. We will generate conditional knockout mice with Celsr3 inactivation in different subtypes of retinal cells and study visual behaviors, ERG, retinal cytoarchitectonics, axonal projections, dendrite development and synapse functions in these mice. Our studies will provide further information of Celsr3 roles in steering neural development, and it is promising to develop Celsr3 as a key target for gene-manipulated therapies after visual injuries.