作为生命科学和微电子学的交叉方向，基于频偏的CMOS磁敏生物传感器在生物大分子检测、医疗检测与诊断等方面都具有重要的应用，是近年来国际上的研究热点。本项目针对免疫分析应用中的超微量生物标志物检测，开发基于频偏的多靶标、超高灵敏度CMOS磁敏生物传感器，该新型传感器将具备40个靶标的检测能力和相当于生物标志物浓度10pg/ml量级的检测灵敏度，并具有在片漂移补偿和微弱信号提取功能。为此需解决的关键问题包括：基于频偏的生物传感器件的结构设计与工艺研发，CMOS高灵敏度、低噪声前端信号采集电路的设计和优化，集成微阵列生物芯片的系统架构设计与优化方法，温漂、时漂校准算法的设计方法与实现和芯片的应用验证。力争通过本项目的研究，突破新一代基于频偏的CMOS磁敏生物传感器中的关键科学与技术难题。

As a frontier interdiscipline of life science and microelectronics, the frequency-shift based CMOS magneto-sensitive biosensor has been widely used in biomolecular detection, medical examination and diagnosis, which is a hotspot in the international research in recent years. To meet the requirements of clinical applications, this project will develop a multi-target and ultra-high sensitivity frequency-shift based CMOS magneto-sensitive biosensor, whose detection sensitivity is in the 10pg/ml order of magnitude and the detection quantity is more than 40. Meanwhile, the weak signal extraction and environmental drift compensation can be fully realized on-chip. To achieve these goals, several key scientific problems will be solved: research and development of the frequency-shift based biosensing device, design and optimization of high sensitivity and low noise CMOS front-end signal acquisition circuit, design and optimization of the system architecture of the integrated microarray biochip, realization of signal processing and calibration algorithm and verification of the practicability of the biochip. The ultimate goal of this research project is to break through the science and technology problems in new generation of frequency-shift based CMOS magneto-sensitive biosensor.