过渡金属催化的苯炔化学研究

三氟甲磺酸(2-三甲基硅基苯)酯在近年来的广泛应用使苯炔化学重获新生。然而，与无过渡金属参与的苯炔化学蓬勃发展不同，过渡金属催化的苯炔化学的发展相对迟缓。其局限性表现在底物范围、催化剂种类、反应类型和反应机制等诸多层面。本项目将基于申请人开发过渡金属催化的新型有机合成反应的经验，以及对苯炔化学发展趋势的预估，通过对底物和反应的精心设计，探索铜催化苯炔双官能团化的三组分反应，铑催化苯并环丁醇或苯并环丁酮与苯炔的碳-碳插入反应，银催化苯炔和炔基酮的[3+2]反应。本项目的成功实施将进一步拓展和丰富过渡金属催化的苯炔化学的底物范围、催化剂种类、反应类型和反应机制。

The aryne chemistry has been re-born in recent years owing to the widespread use of o-trimethylsilylphenyl triflate. However, compared with the significant achievements of transition-metal-free reactions using arynes, the development of transition-metal-catalyzed benzyne chemistry is relatively sluggish. The unsatisfactory situation of this field covers several topics, which are the narrow scope of substrates, the insufficient species of catalysts, the limited types of reactions and the restricted mechanisms of transformations. Based on the applicant’s experience in developing novel transition-metal-catalyzed organic synthetic reactions and prediction of the research trends about benzyne chemistry, this project will explore the Cu-catalyzed double functionalization of arenes using benzyne three-component coupling, the Rh-catalyzed C-C insertion reactions with arynes, the Ag-catalyzed [3+2] reaction between arynes and ynones. These studies would further expand and enrich the transition-metal-catalyzed aryne chemistry in all aspects above-mentioned.