近年来，冠心病已经成为心衰的最主要致病机理，这需要系统地研究冠心病心衰引起的冠状血管网络结构和功能重塑，以便进一步阐明"缺血和心衰间的恶性循环"。通过实验研究、理论分析和数值模拟相结合的方法，本项目将随机重建三维冠状血管网络（包括冠状动脉树，冠状静脉树，毛细血管网络），合并该网络里的搏动血流模型﹑心肌动力学模型﹑血管壁的主动和被动力学模型来建立多尺度（组织和器官间相互作用）和多物理场（流体和固体相互耦合）冠脉循环模型。基于此模型，研究心肌力学、血管壁力学、血流动力学之间的相互作用机制，从而精确预测冠心病心衰的心肌血流灌注和区域分布，以及冠脉血流的自动调节能力。此项研究可用于探索冠心病心衰的微循环治疗手段，从而有助于及早打破"缺血和心衰间的恶性循环"，阻止心衰发展。

Heart failure (HF) is an increasing cause of death in China. The etiology of HF has shifted from mainly valvular disease to coronary heart disease (CHD) during the past two decades. It is of clinical significance to break the vicious cycle of ischemia and HF resulting from CHD, which requires a bioengineering understanding of the highly complex system embedded in the myocardium and of associated mechanical interactions. The general objective of this proposal is to develop a validated model of coronary circulation based on anatomically accurate 3-D coronary vasculature in a dynamic model of the beating heart that integrates myocardium-vessel tissue mechanics; and to use this model to decipher the mechanism of myocardium-vessel-flow interaction. The validated model will specifically elucidate the mechanism underlying the vicious cycle of ischemia and HF which is a very clinically significant issue. The present proposal has the potential to advance scientific knowledge in multiscale modeling and, ultimately, clinical practice in the treatment of HF resulting from CHD.